JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (4): 37-41.doi: 10.6040/j.issn.1671-7554.0.2015.500

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Effect of post-traumatic stress on hippocampal BDNF expression in rats

YUAN Xiuyu1, DONG Yuanjun2, LIANG Xia2, HU Min2, ZHANG Guiqing2   

  1. 1. School of Medicine, Shihezi University, Shihezi 832002, Xinjiang, China;
    2. Department of Rehabilitation Psychology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, Xinjiang, China
  • Received:2015-05-20 Online:2016-04-10 Published:2016-04-10

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Abstract: Objective To investigate changes of brain-derived neurotrophic factor(BDNF)in the hippocampus of rats suffering from post-traumatic stress, and to explore the significance of such changes. Methods A total of 32 Wistar rats were randomly divided into control group and post-traumatic stress group, which was subdivided into 3 groups:1 d group(1 day after modeling, n=8), 7 d group(7 days after modeling, n=8), and 14 d group(14 days after modeling, n=8). Rats in the stress groups were evaluated with open-field test and Morris water maze, and changes in the ethological indexes before and after modeling were assessed, followed by determination of BDNF level in hippocampus of the each group of rats by ELISA. Results BDNF level of the 14 d group was significantly lower than that of the control(Z=-3.363, P=0.001), but there was no difference between the 1 d group and control, 7 d group and control, and 1 d group and 7 d group. Conclusion BDNF level decreases in rats suffering from post-traumatic stress, but such change is rather slow. BDNF is a potential marker for post-traumatic stress.

Key words: Stress, Brain-derived neurotrophic factor, Enzyme linked immunosorbent assay

CLC Number: 

  • R749.5
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