Abstract: To investigate the relations between the genetic polymorphism of short tandem repeat in human Heme Oxygenase1 promoter region and susceptibility of chronic obstructive pulmonary disease. Method: The genetypes of 64 patients with COPD and 56 healthy control subjects were tested with polymerase chain reaction and polyacrylamide gel electrophoresis to analysis the distribution of GT repeat in human Heme Oxygenase1 promoter region. Result: There was no significant difference between COPD patients and control subjects in age， cigarettes years， et al（P＞0.05）， whereas there was significant difference between the two groups about lung function（FEV1： 53.56±8.35％ vs 87.56±5.65％； FEV1/FVC：49.58±7.02％ vs 84.21±6.50％）； The L type allele frequencies in promoter region between COPD patients and control subjects were 21.88% and 10.72%, χ2 analysis showed the statistical significance in two groups； In COPD groups, smoking or not, difference of lung function and age (≤60years and ＞60 years) had no effects on the L type allele frequencies in promoter region.Conclusion: Genetic polymorphism of short tandem repeat in human Heme

Key words: Pulmonary disease, chronic obstructive, Heme oxygenase, Genes, Susceptibilty