Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (5): 54-59.doi: 10.6040/j.issn.1671-7554.0.2024.0785

• Special Topic on Application of Arterial Grafts in Coronary Artery Bypass Grafting • Previous Articles    

del Nido cardioplegia in cardiac surgery: past, present and future

ZHAO Zhimin1, WANG Chun2, LI Bailing1   

  1. 1. Department of Cardiovascular Surgery, First Affiliated Hospital of Naval Medical University, Shanghai 200433, China;
    2. Department of Cardiac Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China
  • Published:2025-05-07

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Abstract: In the past, del Nido cardioplegia was mainly used in pediatric congenital heart disease surgery, but now it is gradually expanding from pediatric congenital heart disease to adult cardiac surgery and is widely used in various cardiac surgeries, including heart valve surgery, large vessel surgery, coronary artery surgery and left heart assist device surgery. With the vigorous development of minimally invasive surgery in cardiac surgery, it is expected that there will be more complete myocardial protection monitoring methods and application strategies in the future, so as to be more conducive to the selection of the most suitable cardioplegia to provide strong support for surgery. The purpose of this review is to summarize the past application, current development and potential application of del Nido cardioplegia in new neighborhoods, in order to provide reference for the development of related fields.

Key words: del Nido cardioplegia, Myocardial preservation, Perfusion, Cardiopulmonary bypass, Myocardial reperfusion injury

CLC Number: 

  • R654
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