Journal of Shandong University (Health Sciences) ›› 2024, Vol. 62 ›› Issue (8): 59-66.doi: 10.6040/j.issn.1671-7554.0.2023.1136

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Mendelian randomization analysis of causality between dietary factors and preeclampsia

ZHANG Zhan1, LI Jianfeng1, LI Yanling1, WANG Bowen1, ANGWEN Chenglinlongzhu3, WANG Xin2, ZHANG Xiaoming2, XIE Ping1   

  1. 1. Department of Cardiovascular Medicine, Gansu Provincial Peoples Hospital;
    2. The First Clinical College of Gansu University of Traditional Chinese Medicine;
    3. The First Clinical Medical College of Lanzhou University, lanzhou 730000, Gansu, China
  • Published:2024-09-20

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Abstract: Objective To explore the potential causal link between dietary factors and preeclampsia. Methods By leveraging Genome-wide association studies(GWAS)data, Mendelian randomization(MR)analyses were employed utilizing Inverse-variance weighted(IVW), Weighted median(WM), and MR-Egger regression techniques to assess the causal association between dietary factors and preeclampsia. Furthermore, heterogeneity tests, sensitivity analyses, and pleiotropy assessments to were conducted ensure the robustness of the findings. Results The analysis revealed a negative causal relationship between preeclampsia and the consumption of cheese(IVW: OR=0.504, 95%CI: 0.314-0.808, P=0.004)as well as salads/raw vegetables(IVW: OR=0.195, 95%CI: 0.041-0.923, P=0.039). All results demonstrated an absence of pleiotropic effects, and the leave-one-out approach further validated the robustness of the findings. No causal associations were observed between preeclampsia and other dietary factors examined. Conclusion A reduced risk of preeclampsia associated with cheese intake and the consumption of salads/raw vegetables is identified in European populations. However, confirmation of these relationships and exploration of the underlying mechanisms require validation using larger GWAS datasets. Additionally, no causal links are established between preeclampsia and the remaining dietary factors investigated.

Key words: Diet, Cheese, Vegetable, Preeclampsia, Mendelian randomization

CLC Number: 

  • R714.7
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