Journal of Shandong University (Health Sciences) ›› 2024, Vol. 62 ›› Issue (7): 48-55.doi: 10.6040/j.issn.1671-7554.0.2024.0534

• 呼吸系统疾病精准诊疗专题 • Previous Articles     Next Articles

Mendelian randomization study of visceral adipose tissue and lung diseases

FENG Yue1,2, YU Yifan1,2, WU Sijia1,2, LI Hongkai1,2, XUE Fuzhong1,2   

  1. 1. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. National Institute of Health Data Science of China, Jinan 250003, Shandong, China
  • Published:2024-09-20

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Abstract: Objective To investigate the causal relationship between obesity and lung diseases using Mendelian randomization(MR)methodology. Methods Employing the inverse variance weighted(IVW)method in conjunction with six distinct MR methodologies, and utilizing summary data from genome-wide association studies(GWAS), the causal relationships between visceral adipose tissue(VAT)and lung diseases, including chronic obstructive pulmonary disease, sleep apnea, lung cancer, pneumonia, pulmonary embolism, idiopathic pulmonary fibrosis and tuberculosis, were assessed. Sensitivity analysis was performed using the leave-one-out method, Cochrans Q test, MR-Egger regression intercept term test, and MR-PRESSO test to evaluate the heterogeneity, pleiotropy, and stability of the instrumental variables. Results The results of the IVW method indicated that genetically predicted higher VAT was causally associated with higher occurrence risks of chronic obstructive pulmonary disease(OR=1.56, 95%CI: 1.33-1.84, P<0.001), sleep apnea(OR=1.76, 95%CI: 1.53-2.03, P<0.001), lung cancer(OR=1.39, 95%CI: 1.23-1.58, P<0.001), and pneumonia(OR=1.22, 95%CI: 1.15-1.30, P<0.001). Except for MR-Egger, the results of the other four MR methods were consistent with the main analysis results. In addition, there was evidence suggested that higher VAT would increase the occurrence risks of pulmonary embolism(OR=1.18, 95%CI: 1.04-1.34, P=0.009)and idiopathic pulmonary fibrosis(OR=1.00, 95%CI: 1.00-1.00, P=0.011). Conclusion VAT accumulation may increase the occurrence risks of chronic obstructive pulmonary disease, sleep apnea, lung cancer, pneumonia, pulmonary embolism and idiopathic pulmonary fibrosis.

Key words: Visceral adipose tissue, Lung diseases, Mendelian randomization, Causal inference, Obesity

CLC Number: 

  • R574
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