Journal of Shandong University (Health Sciences) ›› 2024, Vol. 62 ›› Issue (4): 31-39.doi: 10.6040/j.issn.1671-7554.0.2024.0030

• Clinical Medicine • Previous Articles    

Value of multiple quantitative parameters of EOB-MRI in the risk assessment of progression of HHN in hepatobiliary phase

LIU Xiaowen1,2, CAO Yongquan3, HOU Mingyuan1,4, YU Dexin1   

  1. 1. Department of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Radiology, Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Jinan 250000, Shandong, China;
    3. Department of Radiololgy, Zibo First Hospital, Zibo 255299, Shandong, China;
    4. Department of Radiololgy, Maternal and Child Health Hospital of Weihai, Weihai 264299, Shandong, China
  • Published:2024-05-16

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Abstract: Objective To explore the value of multiple quantitative parameters of gadoxetic acid(gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic(Gd-EOB-DTPA, abbreviated as EOB)enhanced MRI in predicting the risk of progression of hypovascular hypointense nodules(HHN)in hepatobiliary phase(HBP). Methods Patients with HHNs in hepatobiliary phase examined by EOB enhanced MRI(EOB-MRI)in Qilu Hospital of Shandong University were divided into stable group and unstable group through follow-up. The baseline and imaging characteristics of the lesions were observed, and some parameters were measured and calculated. The differences of baseline quantitative parameters between the two groups of HHN were compared. Receiver operating characteristic(ROC)curve was used to analyze the predictive efficiency of each quantitative parameter on nodular stability. Binary Logistic regression was used to analyze the risk factors for the progression of HHN in hepatobiliary phase. Results There were significant differences in the mean value of T2WI signal, contrast-to-noise ratio(CNR)at T2WI and hepatobiliary phase(CNRT2WI, CNRHBP), contrast ratio at hepatobiliary phase(CRHBP)and hepatobiliary phase enhancement rate between the two groups(P=0.045, P=0.037, P=0.043, P=0.049, P=0.003). There were significant differences in apparent diffusion coefficient(ADC)value and CRADC between the two groups(P<0.001, P=0.001). ROC curve analysis showed that hepatobiliary phase enhancement rate, ADC value and CRADC had good predictive power for evaluating HHN stability, with sensitivities of 72.2%, 96.9%, 87.5% and specificities of 72.7%, 54.5% and 63.6%, respectively. High signal intensity on diffusion-weighted imaging(DWI)and the enhancement rate of HHN in hepatobiliary phase were predictors of the progression of HHN in hepatobiliary phase. Conclusion The hepatobiliary phase enhancement rate, ADC value and CRADC of EOB-MRI multi-quantitative parameters are helpful for the risk stratification of HHN in hepatobiliary phase.

Key words: Hypovascular hypointense nodules in hepatobiliary phase, Gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic, Magnetic resonance imaging, Quantitative parameter

CLC Number: 

  • R575
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