Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (1): 38-44.doi: 10.6040/j.issn.1671-7554.0.2022.1150

• 临床医学 • Previous Articles    

Association between carotid calcification and MRI overall burden in 282 cases of cerebral small vessel disease

ZHAO Enju1, ZHAO Shuo2, GUO Yunliang3, WANG Ximing2   

  1. 1. Department of Radiology, The Fourth People s Hospital(Dingtao District People s Hospital)of Heze, Heze 274100, Shandong, China;
    2. Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;
    3. Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China
  • Published:2023-01-10

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Abstract: Objective To investigate the association between carotid calcification and total burden of cerebral small vessel disease(CSVD). Methods Clinical data of 282 CSVD patients who underwent both computed tomography angiography(CTA)and magnetic resonance imaging(MRI)during Jan. 2020 and Jan. 2022 were retrospectively analyzed. Characteristics of carotid calcification(presence, size, number, location, and rim sign)and CSVD total burden(lacunes, white matter hyperintensities, microbleeds, enlarged perivascular space)were assessed. The association between carotid calcification and total burden of CSVD was determined with ordinal multivariable logistic regression. Results Carotid calcification was detected in 125(44.3%)patients. The total burden of CSVD rose significantly with the increasing incidence of carotid calcification(χ2=13.814, P=0.003). There were significant differences in the number(χ2=16.754, P=0.010), location(χ2=17.776, P=0.007)and size(χ2=28.943, P<0.001)of calcification in different CSVD total burden groups, while no significant difference was discovered in rim sign(χ2=4.867, P=0.182). Compared with CSVD 0 group, CSVD 3+ group showed higher incidences of multiple, surface and thick/mixed calcifications. After age, gender, hypertension, diabetes, hyperlipidemia and carotid artery stenosis were adjusted and indexes were remodeled, carotid calcification was an independent risk factor for CSVD total burden(OR=3.687, 95%CI: 1.013-13.423, P=0.048). Conclusion Carotid calcification is closely related to the CSVD total burden, which can act as a potential predictor of the severity of CSVD and help the clinical prevention and treatment.

Key words: Carotid calcification, Cerebral small vessel diseases, Magnetic resonance imaging, Tomography, X-ray computed, Angiography

CLC Number: 

  • R445.2
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