Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (5): 37-43.doi: 10.6040/j.issn.1671-7554.0.2022.0986

• 临床医学 • Previous Articles    

Influencing factors of the transformation of single demyelinating lesion of spinal cord in 47 cases

LI Qing1, ZHANG Anna2, DU Yansheng3, DIAO Jiuzhou3, CUI Ruojin3, FU Pengrui3, YUE Xinyi3, ZHOU Qingbo3   

  1. 1. Department of General Practice, The Second Hospital of Shandong University, Jinan 250033, Shandong, China;
    2. Department of Geriatrics, South Branch of the Second Hospital, Shandong University, Jinan 250013, Shandong, China;
    3. Department of Neurology, The Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Published:2023-05-15

Abstract: Objective To analyze the influencing factors of disease transformation in 47 patients with single demyelinating lesion of spinal cord. Methods The clinical data of 92 patients with single demyelinating lesion of spinal cord were retrospectively analyzed. According to the presence of neuromyelitis optica spectrum disorders(NMOSD), multiple sclerosis(MS), and myelin oligodendrocytes glycoprotein associated disorders(MOG-AD)during the follow-up, the patients were divided into transformed group(n=47)and non-transformed group(n=45). Independent-samples t test, χ2 test, Fishers exact test or Mann-Whitney U test were used to compare the clinical data of the two groups. The independent risk factors of disease transformation were analyzed with binary Logistic regression. Results There were significant association between disease transformation and patients age, visual impairment during follow-up, segments of spinal cord ≥3, abnormality of rheumatic series, positive central nervous system demyelinating antibody and recurrence(P<0.05). Binary Logistic regression analysis showed that recurrence(OR=6.850, 95%CI: 2.206-21.270, P=0.001), segments of spinal cord ≥3(OR=3.968, 95%CI: 1.230-12.805, P=0.021), and positive central nervous system demyelinating antibody(OR=19.983, 95%CI: 2.258-176.816, P=0.007)were independent risk factors of disease transformation. Conclusion The transformation of a single demyelinating lesion of spinal cord is associated with age, visual impairment during follow-up, segments of spinal cord ≥3, positive central nervous system demyelinating antibody, abnormality of rheumatism series and recurrence.

Key words: Demyelination, Myelitis, Recurrence, Transformation, Magnetic resonance imaging, Aquaporin-4

CLC Number: 

  • R741
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