Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (2): 88-94.doi: 10.6040/j.issn.1671-7554.0.2022.0528

• 临床医学 • Previous Articles     Next Articles

Diagnostic value of extracellular volume fraction in 62 cases of different pathological types of lung cancer

YANG Yongqing1,2, ZHAO Peng2, WANG Yu1, MA Wenjing2, TIAN Mimi1, CHENG Yani1, ZU Lu1, LIN Xiangtao1,2   

  1. 1. Medical Integration and Practice Center of Shandong University, Jinan 250012, Shandong, China;
    2. Department of Radiology, Shandong Provincial Hospital, Jinan 250021, Shandong, China
  • Published:2023-02-17

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Abstract: Objective To evaluate the differential diagnostic value of extracellular volume fraction(ECV)in the different pathological types of lung cancer. Methods Sixty-two patients with lung cancer were performed T1 mapping sequence in this prospective study. Areas of interest were delineated on T1 mapping images. The T1 value of lesions and aortic blood pool were measured in the T1 mapping images before and after enhancement. Hematocrit was collected to calculate the ECV. One-way ANOVA was used to compare the differences among the different pathological types of lung cancer. The receiver operating characteristic curve was constructed to analyze its diagnostic value. The sensitivity,specificity and accuracy were calculated. Results A total of 62 patients were included, including 13 cases of small cell lung cancer and 49 cases of non-small cell lung cancer(including 33 cases of adenocarcinoma and 16 cases of squamous cell carcinoma). The mean ECV of small cell lung cancer and non-small cell lung cancer were(13.79±5.93)% and(27.17±6.59)%, respectively. The ECV value of non-small cell lung cancer was higher than small cell lung cancer, and the cut-off value was 18.97%. The sensitivity, specificity and accuracy were 89.8%, 92.3%, and 90.3%, respectively. The average ECV values of adenocarcinoma and squamous cell carcinoma were(24.21±4.92)% and(33.28±5.32)%, respectively, and the difference was statistically significant(P<0.001). The ECV value of carcinoma was higher than adenocarcinoma, the cut-off value was 29.11%, and the sensitivity, specificity and accuracy were 84.8%, 81.2% and 83.7%, respectively. Conclusion ECV can quantitatively analyze the tissue characteristics of lung cancer, and identify the pathological type of lung cancer, with good sensitivity, specificity and accuracy.

Key words: Extracellular volume, Lung cancer, Pathological results, T1 mapping, Magnetic resonance imaging

CLC Number: 

  • R445.2
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