Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (7): 51-56.doi: 10.6040/j.issn.1671-7554.0.2017.1267

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Relationship between PSMD6 gene rs831571 locus polymorphism and the susceptibility of T2DM: a case-control study

TIAN Zhongyan1, LI Yuqian2, LIU Xiaotian1, SHI Yuanyuan1, ZHANG Haiqing1, ZHANG Xia1, QIAN Xinling1, YIN Lei3, ZHAO Jingzhi3, WANG Chongjian1   

  1. 1. Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China;
    2. Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China;
    3. Department of Health Care, Military Hospital in Henan, Zhengzhou 450003, Henan, China
  • Published:2022-09-27

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Abstract: Objective To explore the relationship between PSMD6 gene rs831571 locus polymorphism and the susceptibility of type 2 diabetes mellitus(T2DM)in Henan Han population, and to assess interaction between PSMD6 gene rs831571 locus polymorphism and environmental risk factors. Methods The participants were derived from the Rural 山 东 大 学 学 报 (医 学 版)56卷7期 -田忠艳,等.PSMD6基因rs831571位点多态性与2型糖尿病易感性的病例对照研究 \=-Diabetes, Obesity and Lifestyle(RuralDiab)study in China. A total of 1 052 patients with T2DM(T2DM group)and 1 052 participants without T2DM(control group)were included in the present study after a 1∶1 match based on the age and gender. A custom-by-design 2×48-Plcx SNPscanTM Kit was applied to determine the genotypes of PSMD6 gene rs831571 locus. Logistic regression model was performed to estimate the association between T2DM and PSMD6 gene polymorphism and evaluate the interaction of PSMD6 gene-environmental risk factors. Results Significant difference was observed in the genotype frequencies of PSMD6 gene rs831571 locus in T2DM and control groups(P<0.05). After adjusting smoking, drinking, etc, the genotypes TT(OR=0.623, 95%CI: 0.456-0.853)and CT+TT(OR=0.825, 95%CI: 0.685-0.995)of PSMD6 gene rs831571 locus polymorphism decreased the susceptibility of T2DM. Combined effects analysis revealed that mutant type of MSPD6 with normal BMI or moderate or severe physical activity could attenuate the risk of T2DM, but PSMD6 gene-physical activity and PSMD6 gene-BMI interaction analysis was of no statistical significance(P>0.05). Conclusion PSMD6 gene rs831571 locus polymorphism is associated with the susceptibility of T2DM. In addition, mutant type of PSMD6 with normal BMI or moderate or severe physical activity can attenuate the risk of T2DM. The interactions of PSMD6 gene-physical activity and PSMD6 gene-BMI on T2DM present no statistical significance.

Key words: Type 2 diabetes mellitus, PSMD6 gene polymorphism, Environmental risk factors, Interaction

CLC Number: 

  • R181
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