Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (2): 28-33.doi: 10.6040/j.issn.1671-7554.0.2017.778

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Association between genetic polymorphisms of 5 genetic loci of TNF-α promoter and genetic susceptibility to cervical cancer

ZHAO Qingqing1, YIN Geping2   

  1. 1. Department of Gynecology, Training Base of Jinan Military General Hospital, Jinzhou Medical University, Jinan 250031, Shandong, China;
    2. Department of Gynecology, Jinan Military General Hospital, Jinan 250031, Shandong, China
  • Published:2022-09-28

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Abstract: Objective To investigate the correlation between the genotype and allele frequencies of 5 single nucleotide polymorphisms(SNPs)in the promoter region of tumor necrosis factor-α(TNF-α)gene(rs361525, rs1800629, rs1800750, rs1799964 and rs673)and the susceptibility of cervical cancer in Han women in Shandong Province. Methods The 5 SNPs of TNF-α were genotyped by TaqMan probe and compared with 452 cases of cervical cancer(104 cases of carcinoma in situ and 348 cases of invasive carcinoma)and 494 controls in gene type and frequency. The epidemiological survey and HPV subtype analysis were conducted in the two groups. Results Compared with the control 山 东 大 学 学 报 (医 学 版)56卷2期 -赵庆庆,等.TNF-α 启动子5个位点的基因多态性与山东省汉族妇女宫颈癌遗传易感性的相关性 \=- group, the genetic risk of cervical cancer with rs361525(CT), rs1800629(AG)and rs17999645(AG)genotypes were 3.040(95%CI: 1.761-5.248, P=0.001), 2.580(95%CI: 1.867-3.564, P=0.001), and 3.162(95%CI: 2.332-4.187, P=0.001). The frequency of rs1800750 and rs673 genotypes were not significantly different between cervical cancer group and control group(P=0.929, 0.670). The frequency of genotype of the 5 SNP loci were not statistically different between the invasive cancer group and carcinoma in situ group(P=0.124, 0.455, 0.437, 0.809, 0.868). The HPV infection rate in the cervical cancer group was 91.4%, which was higher than that in the control group(10.3%, P=0.001). The HPV infection rate in the in situ carcinoma was lower than that in invasive carcinoma(77.9% vs 95.4%, P=0.001). Conclusion The genetic polymorphisms of rs361525, rs1800629 and rs17999645 in TNF-α may be genetic risk factors for cervical cancer in Han women in Shandong Province, while there is no significant correlation between rs1800750 and rs673 loci and cervical cancer.

Key words: Uterine cervical neoplasms, Gene polymorphisms, Tumor necrosis factor-α, Genetic susceptibility, Shandong Province, Han nationality

CLC Number: 

  • R711.74
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