JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (9): 73-78.doi: 10.6040/j.issn.1671-7554.0.2016.1387

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Clinicopathological factors and prognosis between primary central and peripheral lung squamous cell carcinoma

LI Xingkai1, LIU Zhanye2, JIANG Yunfeng3, LI Jun1   

  1. 1. Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250012, Shandong, China;
    2. Department of Cardiothoracic Surgery, the County Peoples Hospital of Caoxian, Caoxian 274400, Shandong, China;
    3. Department of Thoracic Surgery, the Second Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2016-10-26 Online:2017-09-10 Published:2017-09-10

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Abstract: Objective To study the clinicopathological features and the prognosis of primary lung squamous cell carcinoma retrospectively and to provide effective methods for diagnosis and treatment. Methods A retrospective study of the clinical data of 447 primary lung cancer patients from January 2009 to December 2012 was made, including 173 cases of central squamous carcinoma and 274 cases of peripheral lung squamous carcinoma. Students t test, Pearson chi-square test, and parametric test of rank transformation were conducted to identify whether there is a significant difference in the clinicopathological factors between central or peripheral lung squamous cell carcinoma. The survival curve was drawn by Kaplan-Meier method, while different survival curves were compared by Log-rank method. Results The difference of sex, age, pathological features, surgical methods, lymph node metastasis of different tumor diameter and differentiated degree, prognosis of lymph node metastases staging were statistically significant. The 1, 3 and 5 year 山 东 大 学 学 报 (医 学 版)55卷9期 -李星凯,等.原发性中央型和周围型肺鳞癌临床病理学及预后差异 \=-survival rate of central squamous carcinomas was 92.70%, 53.60% and 33.76% respectively, and that of peripheral squamous carcinoma was 97.11%, 70.72% and 40.81%. The prognosis between central and peripheral lung squamous cell carcinoma was significantly different(χ2=9.561, P<0.001). Conclusion The constituent ratio between the male and the female showed statistical difference in peripheral and central lung squamous cell carcinoma. Compared with peripheral lung squamous cell carcinoma, central type had a higher rate of lymph node metastasis, poorer prognosis and youth oriented tendency. In addition, it revealed that the rate of lymph node metastasis was positively related with an increasing size and poorer differentiation of the tumor.

Key words: Squamous cell carcinoma, Lung cancer, Lymph node metastasis, Pathological features, Prognosis

CLC Number: 

  • R734.2
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