JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (2): 79-83.doi: 10.6040/j.issn.1671-7554.0.2015.533

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Clinical characteristics and prognosis of 48 patients with mixed phenotype acute leukemia

ZHOU Lanlan, PAN Xueyi, GUO Yu   

  1. Heamotology Department of the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong, China
  • Received:2015-06-01 Online:2017-02-10 Published:2017-02-10

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Abstract: Objective To investigate the clinical and biological characteristics and prognosis of mixed phenotype acute leukemia(MPAL). Methods Forty-eight patients diagnosed with MPAL(MPAL group)by WHO 2008 criteria and 50 patients diagnosed with Ly+AML(Ly+AML group), which is defined as the control group, in the same period were retrospectively analyzed. The cell morphology analysis was performed by swiss and cytochemical staining, the cell immunophenotype was detected by the flow cytometry, the fusion gene of leukemia was detected by fluorescence in situ hybridization, and the chromosome karyotype was analyzed by the standard technique of G-banding. Results The median age of MPAL group was larger than that of Ly+AML group significantly(54 y vs 30 y, P<0.05). The incidence of CD34 positive expression, bnormal karyotype and ph+ in the MPAL group were significantly higher than those in the Ly+AML group(85.4% vs 50%, 65.3% vs 35.7%, 23% vs 0%, all P<0.05). The OS and RFS of MPAL group were significantely lower than those of Ly+AML group(both P<0.05). Conclusion Compared with Ly+AML group, MPAL group has lower OS and RFS; the poor prognosis of MPAL may due to the age, and high incidence of CD34 positive expression and ph+.

Key words: Mixed phenotype acute leukemia, Prognosis, Immunotyping

CLC Number: 

  • R551.3
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