JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (8): 83-86.doi: 10.6040/j.issn.1671-7554.0.2014.721

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Type 2 diabetes mellitus associated with thyroid nodules: a longitudinal health check-up cohort study

LIU Yanxun1, LIU Jia1, ZHANG Tao1, WANG Lu1, XUE Fuzhong1, WANG Ping2   

  1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Shandong University;
    2. Outpatient Operation Room, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-10-17 Published:2015-08-10

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Abstract: Objective To construct a large-scale longitudinal health check-up cohort in urban Chinese population to highlight and confirm the association between type 2 diabetes mellitus and thyroid nodules, to explore the possible factors affecting the formation of thyroid nodule, and to provide guidance for the prevention of thyroid nodules. Methods A longitudinal cohort with 15 528 participants was established based on the routine health check-up systems, and generalized estimating equation (GEE) model was used to detect the association between type 2 diabetes mellitus and thyroid nodules. Results A total of 1 592 cases of thyroid nodules occurred during the 6-year follow-up. The incidence densities of type 2 diabetes mellitus group and healthy group were 36.33 per 1 000 person-years and 28.55 per 1 000 person-years respectively. The difference was statistically significant (χ2=14.80, P <0.001).Our data confirmed and clarified the association between type 2 diabetes mellitus and thyroid nodules (RR=1.299, P= 0.001) after adjusting other potential confounding factors. Conclusion Type 2 diabetes mellitus is associated with thyroid nodules in urban Chinese population.

Key words: Thyroid nodules, Longitudinal cohort study, Generalized estimated equation, Type 2 diabetes mellitus

CLC Number: 

  • R581.3
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