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Effects of Tirofiban on endothelial function in patients with acute myocardial infarction treated by primary percutaneous coronary intervention

LI Yuan-yuan, LAI Qing-you, SHANG De-ya, LIU Dong-xing   

  1. Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2007-11-05 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
  • Contact: LAI Qing-you

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Abstract: To investigate the effects of Tirofiban on endothelial cell function in patients with st-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention. MethodsOne hundred and seventeen patients with primary STEMI who underwent primary PCI were divided into two groups. Sixty patients in the experimental group were treated with Tirofiban, and fifty-seven patients in the control group were treated routinely without Tirofiban. Endothelial cell apoptosis, blood coagulation factor (TF and vWF), and concentration of the cellular adhesion molecules were determined, and the clinical outcomes in the near future were compared. Results Compared with the control group, concentration of the endothelial cell apoptosis, blood coagulation factor, and cellular adhesion molecules were lower in the experimental group (P＜0.05). Incidences of re-infarction and heart failure in the hospital as well as after 30 days were much less in the experimental group compared with the control group(P＜0.05). Conclusions Tirofiban could protect coronary artery endothelial function in patients with STEMI treated by percutaneous coronary intervention, and thereby improves the patient′s clinical outcome in the near future.

Key words: Tirofiban, Myocardial infarction, Percutaneous coronary intervention, Endothelial cell

CLC Number: 

  • R541.4
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