JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Anti-apoptosis effect of insulin-like growth factor-1 on oxidative injured Schwann cells

CONG Li, LI Zhen-hua, SUN Jin-hao, BAO Li-hua   

  1. Department of Anatomy, School of Medicine, Shandong University, Jinan 250012， China
  • Received:2007-09-26 Revised:1900-01-01 Online:2008-03-16 Published:2008-03-16
  • Contact: LI Zhen-hua

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Abstract: To investigate the anti-apoptosis effects of insulin-like growth factor-1 on oxidative injured Schwann cells (SCs). Methods Cultured SCs of rats were divided into the H2O2 group, the H2O2 and IGF-1 group, and the control group. The amounts of intracellular superoxide dismutase (hepatocuprein, SOD) and malondialdehyde（malonaldehyde, MDA）were determined by a biological chemical method, apoptosis was determined by acridine orange staining, and Bcl-2 expression was determined by Western blot. Results Activities of SCs in the oxidative injured group decreased compared with the control group. However, these changes were significantly reversed by the IGF-1 preconditioning. ConclusionIGF-1 has an anti-apoptosis effect on oxidative injured SCs.

Key words: Insulin-like growth factor-1, Schwann cells, Apoptosis

CLC Number: 

  • R322.85
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