JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Expression of WWOX in tissues of breast cancer and its association with ER and menopausal status

YANG Xu-dong， CHEN Jing-han， WANG Xiao-hang， ZHANG Lin   

  1. Department of Thoracic Surgery, Shandong Provincial Hospital, Shandong University,Jinan 250021, Shandong, China
  • Received:2007-01-08 Revised:1900-01-01 Online:2007-09-24 Published:2007-09-24
  • Contact: CHEN Jing-han

PDF (PC)

497

Abstract: Objective： To investigate the expression of E-cadherin and VEGF in esophageal squamous cell carcinoma (ESCC) and the correlation of them with the invasion, metastasis and prognosis of ESCC. Methods： Expressions of E-cadherin and VEGF in 40 specimens of ESCC were determined by immunohistochemistry. Results： The positive rate of E-cadherin in ESCC was 27.5%, lower than that in the control group (P＜0.01). The low expression of Ecadherin correlated with the invasive degree and lymph node metastasis. The positive rate of VEGF in ESCC was 78.0%, higher than that in the control group. The high expression of VEGF correlated with the invasive degree and lymph node metastasis. The expression of E-cadherin was negatively correlated with the expression of VEGF（rs＝-0.4460，P＜0.01）. Conclusions： Expressions of Ecadherin and VEGF correlate with the biological behavior of ESCC, and so it is valuable in evaluating the intensity of metastasis and prognosis of the lymph node.

Key words: Esophageal neoplasms, E-cadherin, Vascular endothelial growth factor, Immunohistochemistry

CLC Number: 

  • R735.1
[1] LI Bo-Bo, LI Dao-Tang, LIU Shu-Guang, WANG Xing-Wu. Expression of serum DKK-1 in esophageal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 58-61.
[2] HUANG Fang, KANG Rui, TUN Chun-Lin. Expressions of VEGF-C，nuclear factor-kappa B and  Survivin in nasopharyngeal carcinoma and their clinical implications [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 83-.
[3] LIN Xueyan, LI Chunyan, HOU Xiaoman, TIAN Yongjie. Expressions of PARP-1 and EMT markers in eutopic and ectopic endometrium of adenomyosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(9): 36-40.
[4] NIE Siyue, WANG Zhen, SUN Jingyu, LIU Jie, LI Juan, WEI Xiaojuan, LU Chunxiao, L(¨overU)Xingyan, WANG Shuyun, SUN Yuping. Expression and clinical significance of angiopoietin-like protein 5 in human gastric cancer tissues [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(8): 61-65.
[5] WANG Yongqiang, ZHANG Weiquan, SUN Qifeng, DONG Xiaopeng, PENG Chuanliang, ZHANG Yuan, ZHAO Xiaogang. Expression and significance of CK14 in non-small cell lung cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 83-87.
[6] ZHANG Xiying, ZHAI Chunyan, LI Jingsong, HAN Bo. Expression of EZH2 in Chinese Ewing sarcoma patients and its relationship with clinicopathological parameters and prognosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 84-91.
[7] LIU Huiling, WANG Xingwen, FENG Shaobin, FENG Hong, HAN Junqing. Association between high expression of scavenger receptor class B type I and the prognosis of colon cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 84-89.
[8] LI Ranran, ZHANG Pengfei, YUAN Bing, FANG Feifei, HAN Mingyong. Breast tumor deriving VEGF induces vascular endothelial cells to suppress immune functions [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 38-43.
[9] WANG Cheng, RONG Yanhua, SHEN Yuming, ZHANG Guoan. Contents and ratios of type I and type III collagens in normal skin and hypertrophic scar in people of different ages [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 64-67.
[10] GU Xu, WANG Xiaqing, REN Wanhua, QIN Chengyong, HAN Guoqing. Expression and clinical significance of NPRL2 and Survivin in hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(6): 68-72.
[11] JIA Zhenjun, QU Yong, ZHANG Shijie. Expressions and significances of HER2 and p53 in different evolution stages of gastric adenocarcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(3): 73-76.
[12] XU Cui, WANG Tao, ZHOU Ping. Immunohistochemical analysis of Helicobacter pylori infection in children [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(9): 81-84.
[13] XU Jiajun, LIU Zongxian, XU Fenglei, WANG Lei, KONG Weihua. Expression of autophagy pathway proteins eIF4E and 4EBP1 in several cerebroma tissues [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(9): 72-76.
[14] FU Qingyuan, DAI Guiqiang, ZHANG Song, AN Hongchun, LIANG Shimin. Effect of panax quinquefolium saponin from stems and leaves on endothelin-1, vascular endothelial growth factor and infarct area in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(9): 30-33.
[15] HUANG Laigang, CUI Baojuan, WANG Xiaohong, WANG Daoqing, ZENG Fanshuo, SUN Min, LIU Benling, SUN Qiangsan. Effect of Ghrelin on the VEGF expression in steroid-induced avascular necrosis of the femoral head in rabbits [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(9): 48-53.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd