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Association analysis of single nucleotide polymorphism in STAT4 gene promoter region with asthma in Chinese Han population from Shandong Province

ZHANG Wen-jing1，LIU Qi-ji1，GAO Gui-min1，LI Huai-chen2，WEI Chun-hua3，GONG Yao-qin1   

  1. 1. Key Laboratory of Experimental Teratology, Ministry of Education, China; Institute of Medical Genetics, School of Medicine; 2. Department of Respiratory Diseases, Shandong Provincial Hospital; 3. Weifang Asthma Hospital
  • Received:2007-06-13 Revised:1900-01-01 Online:2007-12-24 Published:2007-12-24
  • Contact: GONG Yao-qin

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Abstract: ObjectiveTo explore the association of a single nucleotide polymorphism (SNP)， rs16833431 A＞G， in the promoter region of signal transducer and activator of transcription 4 (STAT4) with asthma in Chinese Han population from Shandong Province. MethodsSNP rs16833431 A＞G was genotyped by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) in 220 asthmatic subjects and 233 controls from Shandong Province. Chi-square test was used to determine the association of this SNP with asthma. ResultsThe frequencies of genotypes AA, AG and GG at SNP rs16833431 A＞G were 0.536, 0.377 and 0.086 in asthma patients, while 0.515, 0.399 and 0.086 in healthy controls. ConclusionNo significant difference is observed between STAT4 promoter polymorphism and asthma in Chinese Han population from Shandong Province.

Key words: Signal transducer and activator of transcription 4, Asthma, Polymorphism, single nucleotide, Association

CLC Number: 

  • R394
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