Journal of Shandong University (Health Sciences) ›› 2026, Vol. 64 ›› Issue (4): 117-124.doi: 10.6040/j.issn.1671-7554.0.2025.1013

• Review • Previous Articles    

ATPase copper transporting alpha mediated cuproptosis pathway and its value in cancer therapy

LIN Mingxia, LIU Guibin, MA Yanhua, LIAN Zhaoyu, REN Yangyang   

  1. First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou 730101, Gansu, China
  • Published:2026-04-09

Abstract: The ATPase copper transporting alpha(ATP7A)protein plays a pivotal role in maintaining intracellular copper ion homeostasis, and its aberrant expression in tumors is closely associated with chemoresistance. Cuproptosis, a newly discovered copper-dependent form of cell death, offers innovative strategies for overcoming tumor resistance. However, a systematic overview of how ATP7A mediates cuproptosis and its translational value in cancer therapy is lacking. This review focuses on the dual role of ATP7A in cuproptosis, encompassing the ATP7A-mediated cuproptotic pathway, its physiological functions, and role in copper homeostasis, the mechanisms of ATP7A in tumor chemoresistance, the core molecular pathways regulated by ATP7A in cuproptosis, and the therapeutic strategies targeting the ATP7A-cuproptosis axis in cancer. Integrating high-quality research from recent years, this paper systematically elucidates the potential value and challenges of ATP7A as a therapeutic target in cancer, aiming to provide a theoretical basis and direction for future research in developing precision anti-tumor strategies based on the ATP7A-cuproptosis axis.

Key words: ATP7A, Cuproptosis, Copper homeostasis, Cancer therapy, Drug resistance

CLC Number: 

  • R730.5
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