Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (9): 24-30.doi: 10.6040/j.issn.1671-7554.0.2022.0822

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Ovarian tissue cryopreservation and preservation

RUAN Xiangyan, CHENG Jiaojiao, DU Juan, GU Muqing   

  1. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China
  • Published:2022-09-02

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Abstract: Ovarian tissue cryopreservation and transplantation(OTCT)is a new fertility preservation(FP)technology, which can preserve not only the fertility, but also the ovarian endocrine function. Without ovarian stimulation and delaying anticancer treatment, thousands of follicles can be cryopreserved at one time, and natural pregnancy can be achieved after ovarian tissue transplantation, which is the only way to preserve fertility for prepubertal girls and young women who cannot delay anticancer treatment. In 2019, the American Society of Reproductive Medicine(ASRM)claimed that OTCT was no longer an experimental technique.

Key words: Fertility preservation, Ovarian tissue cryopreservation, Ovarian tissue transplantation, Chemotherapy, Radiotherapy

CLC Number: 

  • R711.6
[1] Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020[J]. CA Cancer J Clin, 2020, 70(1): 7-30.
[2] Rebar RW, Keator CS. Expanding our knowledge of premature ovarian insufficiency[J]. Fertil Steril, 2021,115(2): 328-329.
[3] Dolmans MM, Falcone T, Patrizio P. Importance of patient selection to analyze in vitro fertilization outcome with transplanted cryopreserved ovarian tissue[J]. Fertil Steril, 2020,114(2): 279-280.
[4] Ruan X. Chinese society of gynecological endocrinology affiliated to the international society of gynecological endocrinology guideline for ovarian tissue cryopreservation and transplantation[J]. Gynecol Endocrinol, 2018, 34(12): 1005-1010.
[5] 国际妇科内分泌学会中国妇科内分泌学分会及共识专家. 卵巢组织冻存与移植中国专家共识[J]. 中国临床医生杂志, 2018, 46(4): 496-500.
[6] Dolmans MM, Donnez J, Cacciottola L. Fertility Preservation: The challenge of freezing and transplanting ovarian tissue[J]. Trends Mol Med, 2021, 27(8): 777-791.
[7] Polyzos NP, Ayoubi JM, Pirtea P. General infertility workup in times of high assisted reproductive technology efficacy[J]. Fertil Steril, 2022, 118(1): 8-18.
[8] Anderson RA, Cameron D, Clatot F, et al. Anti-Müllerian hormone as a marker of ovarian reserve and premature ovarian insufficiency in children and women with cancer: a systematic review[J]. Hum Reprod Update, 2022, 28(3): 417-434.
[9] Liebenthron J, Reinsberg J, van der Ven K, et al. Serum anti-Müllerian hormone concentration and follicle density throughout reproductive life and in different diseases-implications in fertility preservation[J]. Hum Reprod, 2019, 34(12): 2513-2522.
[10] Prescott J, Farland LV, Tobias DK, et al. A prospective cohort study of endometriosis and subsequent risk of infertility[J]. Hum Reprod, 2016, 31(7): 1475-1482.
[11] Latif S, Saridogan E, Yasmin E. Fertility preservation for women with ovarian endometriosis: it is time to adopt it as routine practice: FOR: Fertility preservation is an integral component of the management of women with ovarian endometriosis: FOR: Fertility preservation is an integral component of the management of women with ovarian endometriosis[J]. BJOG, 2022. doi: 10.1111/1471-0528.17168.
[12] Hirsch M, Becker C, Davies M. Fertility preservation for women with ovarian endometriosis: it is time to adopt this as routine practice[J]. BJOG, 2022. doi: 10.1111/1471-0528.17166.
[13] Szymanska KJ, Tan X, Oktay K. Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging[J]. Mol Hum Reprod, 2020, 26(8): 553-566.
[14] Ruan X, Cheng J, Du J, et al. Analysis of fertility preservation by ovarian tissue cryopreservation in pediatric children in China[ J]. Front Endocrinol(Lausanne), 2022, 13: 930786. doi: 10.3389/fendo.2022.930786.
[15] Santaballa A,Márquez-Vega C, Rodríguez-Lescureá, et al. Multidisciplinary consensus on the criteria for fertility preservation in cancer patients[J]. Clin Transl Oncol, 2022, 24(2): 227-243.
[16] Corkum KS, Laronda MM, Rowell EE. A review of reported surgical techniques in fertility preservation for prepubertal and adolescent females facing a fertility threatening diagnosis or treatment[J]. Am J Surg, 2017, 214(4): 695-700.
[17] Takae S, Furuta S, Iwahataa H, et al. Cryopreservation of paediatric ovarian tissue with an updated version of the Edinburgh criteria for appropriate patient selection[J]. Reprod Biomed Online, 2022, 44(4): 667-676.
[18] Isachenko E, Isachenko V, Nawroth F, et al. Effect of long-term exposure at suprazero temperatures on activity and viability of human ovarian cortex[J]. Fertil Steril, 2009, 91(4 suppl): 1556-1559.
[19] Beckmann MW, Lotz L, Toth B, et al. Concept paper on the technique of cryopreservation, removal and transplantation of ovarian tissue for fertility preservation[J]. Geburtshilfe Frauenheilkd, 2019, 79(1): 53-62.
[20] Liebenthron J, Montag M, Reinsberg J, et al. Overnight ovarian tissue transportation for centralized cryobanking: a feasible option[J]. Reprod Biomed Online, 2019, 38(5): 740-749.
[21] von Wolff M, Andersen CY, Woodruff TK, et al. Ferti PROTEKT, oncofertility consortium and the Danish fertility-preservation networks- what can we learn from their experiences?[J]. Clin Med Insights Reprod Health, 2019, 13: 1179558119845865. doi:10.1177/1179558119845865.
[22] Liebenthron J, Montag M. Cryopreservation and thawing of human ovarian cortex tissue slices[J]. Methods Mol Biol, 2021, 2180: 485-499.
[23] Khattak H, Malhas R, Craciunas L, et al. Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis[J]. Hum Reprod Update, 2022, 28(3): 400-416.
[24] Hossay C, Donnez J, Dolmans MM. Whole ovary cryopreservation and transplantation: a systematic review of challenges and research developments in animal experiments and humans[J]. J Clin Med, 2020, 9(10): 3196.
[25] Practice Committee of American Society for Reproductive Medicine. Ovarian tissue cryopreservation: a committee opinion[J]. Fertil Steril, 2014, 101(5): 1237-1243.
[26] Donnez J, Dolmans MM, Demylle D, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue[J]. Lancet, 2004, 364(9443): 1405-1410.
[27] Stern CJ, Gook D, Hale LG, et al. First reported clinical pregnancy following heterotopic grafting of cryopreserved ovarian tissue in a woman after a bilateral oophorectomy[J]. Hum Reprod, 2013, 28(11): 2996-2999.
[28] Dolmans MM, von Wolff M, Poirot C, et al. Transplantation of cryopreserved ovarian tissue in a series of 285 women: a review of five leading European centers[J]. Fertil Steril, 2021, 115(5): 1102-1115.
[29] ESHRE Guideline Group on Female Fertility Preservation, Anderson RA, Amant F, et al. ESHRE guideline: female fertility preservation[J]. Hum Reprod Open, 2020, 2020(4): hoaa052. doi: 10.1093/hropen/hoaa052.
[30] Roness H, Meirow D. FERTILITY PRESERVATION: Follicle reserve loss in ovarian tissue transplantation[J]. Reproduction, 2019, 158(5): F35-F44.
[31] Cacciottola L, Nguyen TYT, Chiti MC, et al. Long-term advantages of ovarian reserve maintenance and follicle development using adipose tissue-derived stem cells in ovarian tissue transplantation[J]. J Clin Med, 2020, 9(9): E2980. doi: 10.3390/jcm9092980.
[32] Manavella DD, Cacciottola L, Pommé S, et al. Two-step transplantation with adipose tissue-derived stem cells increases follicle survival by enhancing vascularization in xenografted frozen-thawed human ovarian tissue[J]. Hum Reprod, 2018, 33(6): 1107-1116.
[33] Parrott DMV. The fertility of mice with orthotopic ovarian graftes derived from frozen tissue[J]. Reprod Fertil, 1960, 1: 230-241.
[34] Hovatta O, Silye R, Krausz T, et al. Cryopreservation of human ovarian tissue using dimethylsulphoxide and propanediol-sucrose as cryoprotectants[J]. Hum Reprod, 1996, 11(6): 1268-1272.
[35] Oktay K, Newton H, Mullan J, et al. Development of human primordial follicles to antral stages in SCID/hpg mice stimulated with follicle stimulating hormone[J]. Hum Reprod, 1998, 13(5): 1133-1138.
[36] Oktay K, Karlikaya G. Ovarian function after transplantation of frozen, banked autologous ovarian tissue[J]. N Engl J Med, 2000, 342(25): 1919.
[37] Oktay K, Economos K, Kan M, et al. Endocrine function and oocyte retrieval after autologous transplantation of ovarian cortical strips to the forearm[J]. JAMA, 2001, 286(12): 1490-1493.
[38] Meirow D, Levron J, Eldar-Geva T, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy[J]. N Engl J Med, 2005, 353(3): 318-321.
[39] 阮祥燕, 杜娟, 卢丹, 等. 中国首例冻存卵巢组织移植报告[J]. 首都医科大学学报, 2016, 37(6): 840-842.
[40] Ruan X, Du J, Lu D, et al. First pregnancy in China after ovarian tissue transplantation to prevent premature ovarian insufficiency[J]. Climacteric, 2021, 24(6): 624-628.
[41] Ruan X, Du J, Lu D, et al. First live birth in China after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency[J]. Climacteric, 2022, 25(4): 421-424.
[42] Yding Andersen C, Mamsen LS, Kristensen SG. FERTILITY PRESERVATION: freezing of ovarian tissue and clinical opportunities[J]. Reproduction, 2019, 158(5): F27-F34.
[43] Dolmans MM, Amorim CA. FERTILITY PRESERVATION: construction and use of artificial ovaries[J]. Reproduction, 2019, 158(5): F15-F25.
[44] Dolmans MM, Iwahara Y, Donnez J, et al. Evaluation of minimal disseminated disease in cryopreserved ovarian tissue from bone and soft tissue sarcoma patients[J]. Hum Reprod, 2016, 31(10): 2292-2302.
[45] Jensen AK, Rechnitzer C, Macklon KT, et al. Cryopreservation of ovarian tissue for fertility preservation in a large cohort of young girls: focus on pubertal development[J]. Hum Reprod, 2016, 32(1): 154-164.
[46] Donnez J, Dolmans MM. Fertility preservation in women[J]. N Engl J Med, 2017, 377(17): 1657-1665.
[47] Telfer EE. FERTILITY PRESERVATION: progress and prospects for developing human immature oocytes in vitro[J]. Reproduction, 2019, 158(5): F45-F54.
[48] Dadashzadeh A, Moghassemi S, Shavandi A, et al. A review on biomaterials for ovarian tissue engineering[J]. Acta Biomater, 2021, 135: 48-63.
[49] Lee SH, Sung JH. Organ-on-a-chip technology for reproducing multiorgan physiology[J]. Adv Healthc Mater, 2018,7(2). doi: 10.1002/adhm.201700419.
[50] Kristensen SG, Andersen CY. Cryopreservation of ovarian tissue: opportunities beyond fertility preservation and a positive view into the future[J]. Front Endocrinol(Lausanne), 2018, 9: 347. doi: 10.3389/fendo.2018.00347.
[51] Oktay KH, Marin L, Petrikovsky B, et al. Delaying reproductive aging by ovarian tissue cryopreservation and transplantation: is it prime time?[J]. Trends Mol Med, 2021, 27(8): 753-761.
[52] Kasaven LS, Saso S, Getreu N, et al. Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation?[J]. Hum Reprod, 2022. doi: 10.1093/humrep/deac144.
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