Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (2): 79-84.doi: 10.6040/j.issn.1671-7554.0.2019.1070

Previous Articles     Next Articles

Primary mediastinal seminoma: a case report and literature review

CHEN Rong, LI Haichao, ZHAO Jian   

  1. Department of Thoracic Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Online:2020-02-10 Published:2022-09-27

PDF (PC)

59

Abstract: Objective To improve the recognition of primary mediastinal seminoma. Methods The clinical data of 1 patient with primary mediastinal seminoma were described, and the relevant references were reviewed. Results The patient was 29 years old, and diagnosed as Sertoli cell only syndrome(SCOS)before. Physical examination was negative in serological tests of AFP, β-HCG and etc. The patient was pathologically diagnosed as primary mediastinal seminoma after surgery. Conclusion Surgery and chemotherapy play important roles in the treatment of primary mediastinal seminoma, especially for the early tumors that are expected to be completely resected.

Key words: Primary mediastinal seminoma, Surgery, Chemotherapy, Germ cell tumor, Sertoli cell only syndrome

CLC Number: 

  • R574
[1] Nichols CR. Mediastinal germ cell tumors: clinical features and biologic correlates[J]. Chest, 1991, 99(2): 472-479.
[2] 刘仁伟, 冯丰坔, 刘年元, 等. 纵隔原发性精原细胞瘤的CT表现[J]. 中国医学影像技术, 2012, 28(6): 1131-1134. LIU Renwei, FENG Fengdi, LIU Nianyuan, et al. CT characteristics of primary mediastinal seminoma [J]. Chin J Med Imaging Technol, 2012, 28(6): 1131-1134.
[3] Napieralska A, Majewski W, Osewski W, et al. Primary mediastinal seminoma[J]. J Thorac Dis, 2018, 10(7): 4335-4341.
[4] Cefaro GA, Luzi S, Turriziani A, et al. Primary mediastinal seminoma[J]. Br J Urol, 1988, 62(5): 461-464.
[5] Hainsworth JD. Diagnosis, staging, and clinical characteristics of the patient with mediastinal germ cell carcinoma[J]. Chest Surg Clin N Am, 2002, 12(4): 665-672.
[6] 高玉平, 刘强, 陈以明. 46例纵隔原发性生殖细胞肿瘤的临床病理学分析[J]. 上海交通大学学报(医学版), 2015, 35(5): 702-706. GAO Yuping, LIU Qiang, CHEN Yiming. Clinicopathological analysis of 46 cases of primary mediastinal germ cell tumors[J]. Journal of Shanghai Jiao Tong University Medical Science, 2015, 35(5): 702-706.
[7] 朱姗姗, 杨栋, 周旭辉. 女性原发性前纵隔精原细胞瘤一例报告及文献复习[J]. 中华肿瘤防治杂志, 2011, 18(11): 885-886.
[8] Rosadodechristenson M, Templeton P, Moran C. Mediastinal germ cell tumors: radiologic and pathologic correlation[J]. Radiographics, 1992, 12(5): 1013-1130.
[9] Simson LR, Lampe I, Abell MR. Suprasellar germinomas[J]. Cancer, 1968, 22(3): 533-544.
[10] 方三高, 李晟磊, 陈岗. 2015年WHO肺、胸膜、胸腺及心脏肿瘤分类(胸腺)解读[J]. 重庆医学, 2015, 44(36): 5041-5053.
[11] Mancini M, Carmignani L, Gazzano G, et al. High prevalence of testicular cancer in azoospermic men without spermatogenesis[J]. Hum Reprod, 2007, 22(4): 1042-1046.
[12] 海亚楠. BMP4在人睾丸Sertoli细胞的表达、功能、机制及与无精子症和精原细胞瘤的相关性研究[D]. 上海:上海交通大学, 2015.
[13] Faure AK, Pivot-Pajot C, Kerjean A, et al. Misregulation of histone acetylation in sertoli cell-only syndrome and testicular cancer[J]. Mol Hum Reprod, 2003, 9(12): 757-763.
[14] Puanglumyai S, Lekawanvijit S. An unusual case of sudden unexpected death due to massive hemopericardium from primary mediastinal seminoma[J]. Forensic Sci Int, 2017, 270: e1-e4. doi: 10.1016/j.forsciint.2016.10.003.
[15] Zhang H, Du Y, Liu W, et al. [A case report of primary mediastinal seminoma diagnosised as pulmonary fibrosis] [J]. Zhongguo Fei Ai Za Zhi, 2013, 16(10): 564-566.
[16] Bosemani T, Huisman T, Poretti A. Anti-ma2-associated paraneoplastic encephalitis in a male adolescent with mediastinal seminoma[J]. Pediatr Neurol, 2014, 50(4): 433-434.
[17] Chen CY, Tseng HS, Chen WY, et al. Brain infarction as the initial presentation of primary posterior mediastinal seminoma[J]. Acta Clin Belg, 2011, 66(5): 381-383.
[18] Shin MS, Odrezin GT, Van Dyke JA, et al. Unusual initial calcification of primary and metastatic seminomas: detection by computed tomography[J]. Chest, 1991, 99(6): 1543-1545.
[19] 王官良,罗华荣,沈双双,等.纵隔原发性精原细胞瘤的CT表现与病理对照[J]. 医学影像学杂志, 2013, 23(12): 1941-1943. WANG Guanliang, LUO Huarong, SHEN Shuangshuang, et al. CT features and pathologic findings of primary mediastinal seminoma[J]. J Med Imaging, 2013, 23(12): 1941-1943.
[20] Weissferdt A, Rodriguez-Canales J, Liu H, et al. Primary mediastinal seminomas: a comprehensive immunohistochemical study with a focus on novel markers[J]. Hum Patho, 2015, 46(3): 376-383.
[21] 牛晨,郭丽萍,令潇,等.罕见纵隔原发性精原细胞瘤的CT表现及临床特点[J].现代肿瘤医学, 2016, 24(24): 3937-3940. NIU Chen, GUO Liping, LING Xiao, et al. CT manifestations and clinical features of rare primary mediastinal seminoma[J]. Modern Ocology, 2016, 24(24): 3937-3940.
[22] 薛晨晖,赵兰空.原发性纵隔精原细胞瘤的CT诊断(附12例报告)[J]. 新疆医学, 2013, 43(1): 82-83.
[23] Ueno T, Tanaka YO, Nagata M, et al. Spectrum of germ cell tumors: from head to toe[J]. Radiographics, 2004, 24(2): 387-404.
[24] Fernández-Friera L, Fuster V, Sanz J. Characterization of a mediastinal thymic seminoma using cardiac magnetic resonance[J]. Rev Esp Cardiol(Engl Ed), 2012, 65(1): 97. doi: 10.1016/j.recesp.2010.03.005.
[25] Drevelegas A, Palladas P, Scordalaki A. Mediastinal germ cell tumors: a radiologic-pathologic review[J]. Eur Radiol, 2001, 11(10): 1925-1932.
[26] 李才林, 代云蒙, 曾珍,等. 精原细胞瘤的影像学表现及其病理学基础[J]. 实用放射学杂志, 2018, 34(2): 241-244. LI Cailin, DAI Yunmeng, ZENG Zhen, et al. Imaging features and pathological basis of seminoma[J]. J Pract Radio, 2018, 34(2): 241-244.
[27] Bukowski RM, Wolf M, Kulander BG, et al. Alternating combination chemotherapy in patients with extragonadal germ cell tumors: a southwest oncology group study[J]. Cancer, 1993, 71(8): 2631-2638.
[28] Sakurai H, Asamura H, Suzuki K, et al. Management of primary malignant germ cell tumor of the mediastinum[J]. Jpn J Clin Oncol, 2004, 34(7): 386-392.
[29] Bokemeyer C, Hartmann JT, Fossa SD, et al. Extragonadal germ cell tumors: relation to testicular neoplasia and management options[J]. APMIS, 2003, 111(1): 49-63.
[30] 王鹏远,段学宁,刘玉村,等.胸骨后甲状腺肿的诊断与手术治疗[J]. 中华普通外科杂志, 2008, 23(3): 209-211. WANG Pengyuan, DUAN Xuening, LIU Yucun, et al. Diagnosis and surgical therapy of substernal goiter[J]. Chinese Journal of General Surgery, 2008, 23(3): 209-211.
[31] Sakaguchi Y, Isowa N. Successful resection of mediastinal seminoma evaluated the response to induction chemotherapy with fluorodeoxyglucose-positron emission tomography[J]. Ann Thorac Cardiovasc Surg, 2012, 18(1): 45-47.
[32] Fedyanin M, Tryakin A, Bulanov A, et al. Chemotherapy efficacy and prognosis of patients with mediastinal seminoma. Single institution experience[J]. J Clin Oncol, 2016, 34(15_suppl): e16053.
[33] 付晓红. 霍奇金淋巴瘤预后因素研究及原发纵隔恶性生殖细胞瘤临床分析[D].广州:中山大学, 2008.
[34] Fizazi K, Culine S, Droz JP, et al. Initial management of primary mediastinal seminoma: radiotherapy or cisplatin-based chemotherapy?[J]. Eur J Cancer, 1998, 34(3): 347-352.
[35] Jyothirmayi R, Ramadas K, Jacob R, et al. Primary malignant germ cell tumours of the mediastinum - results of multimodality treatment[J]. Acta Oncol, 1997, 36(3): 317-321.
[36] Hartmann JT, Fossa SD, Nichols CR, et al. Incidence of metachronous testicular cancer in patients with extragonadal germ cell tumors[J]. J Natl Cancer Inst, 2001, 93(22): 1733-1738.
[1] RUAN Xiangyan, CHENG Jiaojiao, DU Juan, GU Muqing. Ovarian tissue cryopreservation and preservation [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 24-30.
[2] FU Jia, WANG Lulu, HU Shuai, CHEN Zheping, LIU Dongyi, LI Qingsong, LU Guodong, ZHANG He, ZHAO Xin, FENG Chang. Effects of different approaches of quadrates lumborum block on postoperative recovery of patients undergoing radical gastrectomy [J]. Journal of Shandong University (Health Sciences), 2022, 60(8): 50-57.
[3] TIAN Chaoqun, LYU Yafeng, LI Xiaofei, SONG Yongdong, KONG Ligang, FAN Zhaomin, WANG Haibo, ZHANG Daogong. Comparison of the efficacy between semicircular canal plugging and labyrinthectomy for intractable Menieres disease [J]. Journal of Shandong University (Health Sciences), 2022, 60(8): 30-33.
[4] GAO Zhongxia, ZHANG Ming, FAN Mingde, TAN Chenyang, WANG Mengdi, WANG Chao, FAN Yuefei, DING Shouluan, WANG Chengwei. Efficacy and prognostic factors of gamma knife in treating 81 cases of brain metastases from lung cancer [J]. Journal of Shandong University (Health Sciences), 2022, 60(8): 44-49.
[5] Xinmei ZHANG,Ping XU. Surgical treatment strategies of adenomyosis [J]. Journal of Shandong University (Health Sciences), 2022, 60(7): 26-31.
[6] QIN Jing, YANG Fei, CHEN Qian, XIA Handai, LIU Yanguo, WANG Xiuwen. A network meta-analysis of first-line treatment options for patients with advanced driver-gene wild-type and PD-L1 negative non-squamous non-small cell lung cancer [J]. Journal of Shandong University (Health Sciences), 2022, 60(7): 74-82.
[7] YAO Xue, LU Ranran, SUN Shuling, GAO Cuiping, XIAO Ru, WANG Shuhui. Establishment of a risk prediction scoring model for nosocomial infection in rheumatic heart disease patients after valve replacement surgery [J]. Journal of Shandong University (Health Sciences), 2022, 60(6): 90-96.
[8] LI Mingbo, HUANG Yanbo, REN Dongcheng, LIU Juncheng, TAN Chengshuang, XU Jixi, DING Jinyong. Afinite element analysis of three different fusion methods of lumbar internal fixation [J]. Journal of Shandong University (Health Sciences), 2022, 60(1): 55-64.
[9] Mingwei ZHONG,Sanyuan HU. Exploration of surgical treatment of obesity by laparoscopic techniques in China [J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 72-77, 96.
[10] Jun YANG. Medico-engineering cooperation: a strategic plateau of neurosurgery innovation and development in the era of precision medicine [J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 83-88.
[11] Zhuxiu CHU,Wenjing ZHAO,Xiaoyan LI,Xiaoli KONG,Tingting MA,Liyu JIANG,Qifeng YANG. Significance of neoadjuvant chemotherapy and molecular marker changes in 218 women with breast cancer [J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 130-139.
[12] WANG Zhe, LIU Yujie, MAO Qian, GUAN Peixia, BAO Qihan, LI Chengsheng, QIAO Xiaowei, PAN Qingzhong, WANG Suzhen. Evaluation of the efficacy of different regimens for early triple negative breast cancer based on the inverse probability of treatment weighting method [J]. Journal of Shandong University (Health Sciences), 2021, 59(8): 113-118.
[13] LIU Xueyan, WANG Guangpeng, YAO Xue, LU Ranran, WANG Shuhui. Analysis of economic burden and length of hospital stay of nosocomial infection in neurosurgery patients [J]. Journal of Shandong University (Health Sciences), 2021, 59(10): 87-93.
[14] WANG Liangliang, ZHANG Ming, SUN Zhenwei, DING Shouluan, FAN Yuefei, WANG Chengwei. Comparison of efficacy of gamma knife radiosurgery and microvascular decompression in the treatment of primary trigeminal neuralgia [J]. Journal of Shandong University (Health Sciences), 2021, 59(1): 28-33.
[15] Jizong ZHAO. Neurosurgery plays a key role in brain science research [J]. Journal of Shandong University (Health Sciences), 2020, 1(8): 1-4.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd