Abstract: Objective To explore the relationship between bone mineral density(BMD), bonemetabolismrelated indicators and coronary artery calcification(CAC)in order to provide reference for the screening of high-risk CAC population. Methods This study involved 138 subjects(39-81 years)who underwent coronary artery CT angiography(CTA)during June 2018 and May 2019. According to the BMD results, the subjects were divided into osteoporosis group, osteopenia group and healthy group. The coronary artery calcium scoring(CACS)was calculated with Agatston score(AS), and the total CACS was obtained by summing up the scores of the branches. Based on the total CACS, the subjects were divided into CAC group(>10)and non-CAC group(≤10). The bone metabolism related indicators were recorded, including total Ⅰ type collagen amino peptide(tP1NP), extended β-Ⅰ type collagen peptide(β-CTx), fetal globulin A(Fetuin-A), parathyroid hormone(PTH), and other biochemical indicators. Results There were statistically significant differences in gender(P<0.001), age(P<0.001), pressure difference(P=0.01), fasting blood glucose(P<0.001), menopause(P=0.04), drinking history(P<0.001), smoking history(P<0.001), and lumbar spine density(P=0.01)between the CAC group and non-CAC group. There were no significant differences in tP1NP,β-CTx,PTH,Fetuin-A and ALP between the two groups(P>0.05). CACS was correlated with gender, age, differential pressure, 山 东 大 学 学 报 (医 学 版)58卷2期 -李娜,等.138例39~81岁体检人员血管钙化指标的关联分析 \=- fasting blood glucose, lumbar spinedensity, menopause, history of drinking and smoking. Age, fasting bloodglucose and lumbar spine density had a certain effect on CAC score. Conclusion In middle-aged and elderly people, lumbar spine densityis correlated with CAC and can be used as a predictor.

Key words: Vascular calcification, Osteoporosis, Bone density, Total Ⅰ type collagen amino peptide, Extended β-Ⅰ type collagen peptide