Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (12): 43-46.doi: 10.6040/j.issn.1671-7554.0.2020.0925

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Clinical observation of PEG-rhG-CSF in preventing neutropenia in 80 patients with small cell lung cancer treated with concurrent chemoradiotherapy

ZHANG Xiqin1,2, ZHU Shouhui2, LIU Ning2, WANG Yu2, CHEN Jiazhen2, HU Xudong2   

  1. 1. Shandong First Medical University, Jinan 250000, Shandong, China;
    2. Department of Radiation Oncology, Affiliated Cancer Hospital of Shandong First Medical University, Jinan 250117, Shandong, China
  • Published:2020-12-08

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Abstract: Objective To investigate the preventive effect of pegylated recombinant human granulocyte colony stimulating factor(PEG-rhG-CSF)on neutropenia in patients with small cell lung cancer(SCLC). Methods A retrospective analysis of 80 SCLC cases(observation group)who received concurrent chemoradiotherapy and prophylactic use of PEG- rhG-CSF in Shandong Cancer Hospital was conducted, and 80 controls without useing PEG-rhG-CSF were matched according to age, gender and other factors. The neutropenia was observed and compared between the two groups. Results After concurrent chemoradiotherapy, the leukocytes count decreased in both groups, which was(3.15±0.76)×109 cells/L in the observation group and(1.82±0.77)×109 cells/L in the control group (Z=-8.467, P<0.001). Before chemoradiotherapy, there was no significant difference in the absolute value of neutrophils between the two groups(Z=-1.543, P=0.123). After chemoradiotherapy, the number of neutrophils decreased to(1.89±0.52)×109 cells/L in the observation group and(0.77±0.44)×109 cells/L in the control group. The decrease in the observation group was lower than that in the control group (Z=-10.034, P<0.001). Conclusion PEG-rhG-CSF can prevent the decrease of leukocytes and neutrophils, but experiments with larger samples are still needed for proof.

Key words: Pegylated recombinant human granulocyte colony stimulating factor, Small cell lung cancer, Concurrent radiotherapy and chemotherapy, Myelosuppression, Preventive effect

CLC Number: 

  • R734.2
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