JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (11): 36-39.doi: 10.6040/j.issn.1671-7554.0.2015.412

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Diagnostic value of combination of PCT and NSE in serum for detecting small cell lung cancer

ZHANG Zhiqiang1, WU Yanhua1, WANG Maoshui1, WANG Xinfeng1, WANG Yunshan2   

  1. 1. Department of Laboratory Medicine, Shandong Provincial Chest Hospital, Jinan 250013, Shandong, China;
    2. Cental Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China
  • Received:2015-04-23 Online:2016-11-10 Published:2016-11-10

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Abstract: Objective To investigate the diagnostic value of combination of procalcitonin(PCT)and neuron-specific enolase(NSE)in serum for differentiating small cell lung cancer from other lung cancers. Methods A total of 123 lung cancer patients without lung infections, other sites infection history and liver metastasis were divided into three groups: squamous carcinoma group(n=48), adenocarcinoma group(n=52)and small cell carcinoma group(n=23). And 40 healthy volunteers were taken as control group. Serum PCT and NSE levels were tested and compared among each group. Results Serum PCT and NSE levels were statistical different among the four groups(P<0.01). Mann-Whitney analysis showed that, there were statistical differences between small cell carcinoma and squamous carcinoma or adenocarcinoma groups(P<0.05, P<0.01). For PCT and NSE, the area under the ROC curve was 0.671 and 0.806, the best cut-off point was 0.10 and 23.91 ng/mL, sensitivity was 56.5% and 69.6%, and specificity was 77.0% and 90.0%. Combination(PCT+NSE)would increase the specificity to 98.0%, while combination(PCT or 山 东 大 学 学 报 (医 学 版)54卷11期 -张志强,等.联合检测血清PCT和NSE对小细胞肺癌的诊断价值 \=-NSE)would increase the sensitivity to 82.6%. Conclusion PCT can be used as a marker in differentiating small cell lung cancer from other lung cancers. However, for the small cell lung cancer patients, serum PCT cannot be simply used to detect the infection. Meanwhile, combined biomarkers(PCT and NSE)will improve the diagnostic performance in discrimination of small cell lung cancer.

Key words: Small cell lung cancer, Neuron specific enolase, ROC curve, Procalcitonin

CLC Number: 

  • R734.2
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