JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (11): 36-39.doi: 10.6040/j.issn.1671-7554.0.2015.412

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Diagnostic value of combination of PCT and NSE in serum for detecting small cell lung cancer

ZHANG Zhiqiang1, WU Yanhua1, WANG Maoshui1, WANG Xinfeng1, WANG Yunshan2   

  1. 1. Department of Laboratory Medicine, Shandong Provincial Chest Hospital, Jinan 250013, Shandong, China;
    2. Cental Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China
  • Received:2015-04-23 Online:2016-11-10 Published:2016-11-10

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Abstract: Objective To investigate the diagnostic value of combination of procalcitonin(PCT)and neuron-specific enolase(NSE)in serum for differentiating small cell lung cancer from other lung cancers. Methods A total of 123 lung cancer patients without lung infections, other sites infection history and liver metastasis were divided into three groups: squamous carcinoma group(n=48), adenocarcinoma group(n=52)and small cell carcinoma group(n=23). And 40 healthy volunteers were taken as control group. Serum PCT and NSE levels were tested and compared among each group. Results Serum PCT and NSE levels were statistical different among the four groups(P<0.01). Mann-Whitney analysis showed that, there were statistical differences between small cell carcinoma and squamous carcinoma or adenocarcinoma groups(P<0.05, P<0.01). For PCT and NSE, the area under the ROC curve was 0.671 and 0.806, the best cut-off point was 0.10 and 23.91 ng/mL, sensitivity was 56.5% and 69.6%, and specificity was 77.0% and 90.0%. Combination(PCT+NSE)would increase the specificity to 98.0%, while combination(PCT or 山 东 大 学 学 报 (医 学 版)54卷11期 -张志强,等.联合检测血清PCT和NSE对小细胞肺癌的诊断价值 \=-NSE)would increase the sensitivity to 82.6%. Conclusion PCT can be used as a marker in differentiating small cell lung cancer from other lung cancers. However, for the small cell lung cancer patients, serum PCT cannot be simply used to detect the infection. Meanwhile, combined biomarkers(PCT and NSE)will improve the diagnostic performance in discrimination of small cell lung cancer.

Key words: Small cell lung cancer, Neuron specific enolase, ROC curve, Procalcitonin

CLC Number: 

  • R734.2
[1] Assicot M, Gendrel D, Carsin H, et al. High serum procalcitonin concentrations in patients with sepsis and infection[J]. Lancet, 1993, 341(8844): 515-518.
[2] 王信杰,杜向阳.降钙素原与腺苷脱氨酶联合检测诊断结核性胸腔积液[J].山东大学学报(医学版), 2012, 50(9): 79-82. WANG Xinjie, DU Xiangyang. Combined detection of procalcitonin and adenosine deaminase for tuberculous pleural effusion[J]. Journal of Shandong University(Health Sciences), 2012, 50(9): 79-82.
[3] Sandri MT, Passerini R, Leon ME, et al. Procalcitonin as a useful marker of infection in hemato-oncological patients with fever[J]. Anticancer Res, 2008, 28(5B): 3061-3065.
[4] 刘平平,郑力,张浩,等. PCT和C-反应蛋白在恶性肿瘤合并感染的早期诊断价值[J].浙江临床医学, 2014, 16(9): 1383-1384. LIU Pingping, ZHENG Li, ZHANG Hao, et al. PCT and C-reactive protein in early diagnosis of infection in the patients with malignant tumor[J]. Zhejiang Clinical Medical Journal, 2014, 16(9): 1383-1384.
[5] Kallio R, Surcel HM, Bloigu A, et al. C-reactive protein, procalcitonin and interleukin-8 in the primary diagnosis of infections in cancer patients [J]. Eur J Cancer,2000, 36(7): 889-894.
[6] Russwurm S, Stonans I, Stonane E, et al.Procalcitonin and CGRP-1 mrna expression in various human tissues[J]. Shock, 2001, 16(2): 109-112.
[7] 上官红,肖伟,董亮,等.血清CYFRA21-1、NSE和CEA在肺癌诊断和评估预后中的临床价值[J].山东大学学报(医学版), 2010, 48(12): 134-137. SHANGGUAN Hong, XIAO Wei, DONG Liang, et al. Clinical value of serum CYFRA21-1, NSE and CEA in the diagnosis and prognosis of lung cancer [J]. Journal of Shandong University(Health Sciences), 2010, 48(12): 134-137.
[8] 陈孝谦,汪铮,李秀.血清降钙素原对渗出性胸腔积液病因的鉴别价值[J].临床肺科杂志, 2013, 18(8): 1446-1448. CHEN Xiaoqian, WANG Zheng, LI Xiu. Value of serum procalcitonin in the differentiation of causes of pleural exudates [J]. Journal of Clinical Pulmonary Medicine, 2013, 18(8): 1446-1448.
[9] Cate CC, Pettengill OS, Sorenson GD. Biosynthesis of procalcitonin in small cell carcinoma of the lung[J]. Cancer Res, 1986, 46(2): 812-818.
[10] Mehanic S, Baljic R. The importance of serum procalcitonin in diagnosis and treatment of serious bacterial infections and sepsis[J]. Mater Sociomed, 2013, 25(4): 277-281.
[11] 佟威威,佟广辉,王婧,等. Cyfra21-1、NSE、SCCA和CRP在肺癌诊断中的应用[J].中国免疫学杂志, 2015, 31(3): 396-400. TONG Weiwei, TONG Guanghui, WANG Jing, et al. Value of Cyfra21-1, NSE, SCCA and CRP in diagnosis of lung cancer[J]. Chinese Journal of Immunology, 2015, 31(3): 396-400.
[12] Lortet-Tieulent J, Soerjomataram I, Ferlay J, et al. International trends in lung cancer incidence by histological subtype: adenocarcinoma stabilizing in men but still increasing in women[J]. Lung Cancer, 2014, 84(1): 13-22.
[13] Falsey AR, Becker KL, Swinbume AJ, et al. Utility of serum procalcitonin values in patients with acute exacerbations of chronic obstrutive pulmonary disease: a cautionary note[J]. Int J Chron Obstruct Pulmon Dis, 2012, 7: 127-135.
[14] Schuetz P, Maurer P, Punjabi V, et al. Procalcitonin decrease over 72 hours in US critical care units predicts fatal outcome in sepsis patients[J]. Crit Care, 2013, 17(3): R115-R122.
[15] 叶倩,陈燕,罗玲青,等.血清降钙素原及C反应蛋白在鉴别肿瘤患者发热原因中的价值[J].国际检验医学杂志, 2014, 35(19): 2064-2066. YE Qian, CHEN Yan, LUO Lingqing, et al.The value of serum procalcitonin and C-reactive protein in the differentiation of the causes of fever in cancer patients[J]. International Journal of Laboratory Medicine, 2014, 35(19): 2064-2066.
[16] Ukay I, Garzoni C, Ferry T, et al. Postoperative serum pro-calcitonin and C-reactive protein levels in patients with orthopedic infections[J]. Swiss Med Wkly, 2010, 140: w13124.
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