Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (12): 26-30.doi: 10.6040/j.issn.1671-7554.0.2022.0567

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Association between sleep disturbance and inflammatory cytokines in 203 patients with glioma

LI Huayu1, SHI Xiaohan1, ZHANG Xinrui1, LI Feng2   

  1. 1. School of Nursing and Rehabilitation, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Neurosurgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong, China
  • Published:2022-12-01

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Abstract: Objective To investigate the incidence of sleep disturbance and the inflammatory factors related to sleep disturbance in patients with glioma. Methods A total of 203 patients with glioma admitted during Dec. 2020 and Dec. 2021 were surveyed with Pittsburgh Sleep Quality Index(PSQI). The plasma inflammatory cytokines were measured. The independent risk factors of sleep disturbance were identified with univariate analysis and binary Logistic regression. The robustness and accuracy of the prediction model were confirmed with support vector machine(SVM)model. Results Of all 203 patients, 52.7% had sleep disturbance. Binary Logistic regression analysis showed that receiving surgery(OR=0.491, 95%CI=0.245-0.985, P=0.045)was a protective factor, while increased expressions of IL-1β(OR=1.838, 95%CI=1.070-3.158, P=0.028)and IL-6(OR=3.627, 95%CI=1.453-9.054, P=0.006)were risk factors. The results of SVM model demonstrated the area under the receiver operating characteristic(AUC)of the prediction model was 0.793, and the accuracy was 0.720(95%CI=0.575-0.838). Conclusion The incidence of sleep disturbance in glioma patients is high, and elevated expressions of IL-1β and IL-6 are closely related to the risk of sleep disturbance.

Key words: Glioma, Sleep disturbance, Inflammation, Cytokines, Biological mechanism

CLC Number: 

  • R739.41
[1] Zhang H, Luo YB, Wu W, et al. The molecular feature of macrophages in tumor immune microenvironment of glioma patients [J]. Comput Struct Biotechnol J, 2021, 19: 4603-4618. doi: 10.1016/j.csbj.2021.08.019.
[2] Morgan LL. The epidemiology of glioma in adults: a “state of the science” review [J]. Neuro Oncolo, 2015, 17(4): 623-624.
[3] Huang Y, Jiang ZJ, Deng J, et al. Sleep quality of patients with postoperative glioma at home [J]. World J Clin Cases, 2020, 8(20): 4735-4742.
[4] Armstrong TS, Shade MY, Breton G, et al. Sleep-wake disturbance in patients with brain tumors [J]. Neuro-Oncology, 2017, 19(3): 323-335.
[5] Dantono B, Bouchard V. Impaired sleep quality is associated with concurrent elevations in inflammatory markers: are post-menopausal women at greater risk? [J]. Biol Sex Differ, 2019, 10(1): 34.
[6] Buysse DJ, Reynolds CF, Monk TH, et al. The pittsburgh sleep quality index-a new instrument for psychiatric practice and research [J]. Psychiatry Res, 1989, 28(2): 193-213.
[7] Jeon MS, Dhillon HM, Agar MR. Sleep disturbance of adults with a brain tumor and their family caregivers: a systematic review [J]. Neuro Oncol, 2017, 19(8): 1035-1046.
[8] 宋丽, 姚兰. 胶质瘤切除术后患者睡眠障碍的危险因素[J]. 中华麻醉学杂志, 2020, 40(12): 1440-1442.
[9] Xu J, Wang J, Wimo A, et al. The economic burden of mental disorders in China, 2005-2013: implications for health policy [J]. BMC Psychiatry, 2016, 16(1): 137.
[10] Irwin MR, Olmstead R, Breen EC, et al. Tai chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: a randomized controlled trial [J]. J Natl Cancer Inst Monogr, 2014, 2014(50): 295-301.
[11] Alam MN, Mcginty D, Bashir T, et al. Interleukin-1beta modulates state-dependent discharge activity of preoptic area and basal forebrain neurons: role in sleep regulation [J]. Eur J Neurosci, 2004, 20(1): 207-216.
[12] Tucker JA, Osann K, Hsieh S, et al. Longitudinal changes in sleep: associations with shifts in circulating cytokines and emotional distress in a cancer survivor population [J]. Int J Behav Med, 2021, 28(1): 140-150.
[13] Irwin MR, Cole SW. Reciprocal regulation of the neural and innate immune systems [J]. Nat Rev Immunol, 2011, 11(9): 625-632.
[14] Elaraj DM, Weinreich DM, Varghese S, et al. The role of interleukin 1 in growth and metastasis of human cancer xenografts [J]. Clin Cancer Res, 2006, 12(4): 1088-1096.
[15] Liu X, Nemeth DP, Mckim DB, et al. Cell-type-specific Interleukin 1 receptor 1 signaling in the brain regulates distinct neuroimmune activities [J]. Immunity, 2019, 50(2): 317-333.
[16] Taishi P, Davis CJ, Bayomy O, et al. Brain-specific interleukin-1 receptor accessory protein in sleep regulation[J]. J Appl Physiol(1985), 2012, 112(6): 1015-1022.
[17] 宋利, 周杰, 陈礼刚. 脑胶质瘤患者HPA轴-炎症与行为症状相关性的研究进展[J]. 中华神经外科杂志, 2019,35(8): 858-862.
[18] Opp MR. Cytokines and sleep[J]. Sleep Med Rev, 2005, 9(5): 355-364.
[19] Barreto FS, Chaves AJM, De Araujo MCCR, et al. Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer [J]. Behav Pharmacol, 2018, 29(2-3): 165-180.
[20] Dantzer R, Oconnor JC, Lawson MA, et al. Inflammation-associated depression: from serotonin to kynurenine [J]. Psychoneuroendocrinology, 2011, 36(3): 426-436.
[21] Monti JM. The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement(REM)sleep [J]. Sleep Med Rev, 2010, 14(5): 319-327.
[22] Irwin MR, Opp MR. Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity [J]. Neuropsychopharmacology, 2017, 42(1): 129-155.
[23] Imeri L, Opp MR. How(and why)the immune system makes us sleep [J]. Nat Rev Neurosci, 2009, 10(3): 199-210.
[24] Bjurström MF, Olmstead R, Irwin MR. Reciprocal relationship between sleep macrostructure and evening and morning cellular inflammation in rheumatoid arthritis [J]. Psychosom Med, 2017, 79(1): 24-33.
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