Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (12): 19-25.doi: 10.6040/j.issn.1671-7554.0.2022.0976

• 临床医学 • Previous Articles    

Efficacy of ultra-low frequency transcranial magnetic stimulation in patients with Parkinsons disease sleep disorders

TIAN Xiangqi, WANG Hao, XU Xinrong, FANG Yuqing, MAO Fei, ZHAO Zhangning, ZHAO Hailong, WU Bingyun, LI Xiuhua   

  1. Department of Neurology, The First Affiliated Hospital of Shandong First Medical University &
    Shandong Provincial Qianfoshan Hospital, Shandong Institute of Neuroimmunology, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan 250014, Shandong, China
  • Published:2022-12-01

PDF (PC)

223

Abstract: Objective To observe the efficacy of ultra-low frequency transcranial magnetic stimulation(ULF-TMS)in the treatment of patients with Parkinsons disease sleep disorder(PDSD), and to explore the possible mechanism. Methods A total of 90 PDSD patients were randomly divided into gamma aminobutyric acid(GABA)group, 5-hydroxytryptamine(5-HT)group and control group, with 30 cases in each group, receiving GABA characteristic magnetic stimulation, 5-HT characteristic magnetic stimulation and sham stimulation, respectively, once a day for 35 minutes for 7 days. All patients routinely took anti-Parkinson drugs. The scores of Pittsburgh Sleep Quality Index(PSQI), Parkinsons Disease Sleep Scale(PDSS), Epworth Sleepiness Scale(ESS), Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)were monitored 1 day before treatment, 1 day and 30 days after treatment. Results There were significant differences in the time point factors, time point and group interaction of PSQI, PDSS, ESS, HAMD and HAMA scores at the three time points(P<0.001), but there were no significant differences in group factors(P>0.05). Pairwise comparison showed that in the same group, the scores of PSQI, ESS, HAMD and HAMA in the GABA and 5-HT groups decreased(P<0.05), while PDSS score increased(P<0.05)on the day 1 after treatment compared with those 1 day before treatment, but there were no significant differences in PSQI, PDSS, ESS, HAMD and HAMA scores 1 day before treatment and 30 days after treatment(P>0.05). The scores of PSQI, ESS, HAMD and HAMA in GABA and 5-HT groups were lower than those in the control group on day 1 after treatment(P<0.05), while the score of PDSS were higher(P<0.05). The scores of PSQI, PDSS, ESS, HAMD and HAMA were not significantly different 30 days after treatment(P>0.05). Conclusion ULF-TMS can improve sleep quality and mood disorder in PDSD patients in the short term.

Key words: Ultra-low frequency transcranial magnetic stimulation, Parkinsons disease, Sleep disorder, Gamma aminobutyric acid, 5-hydroxytryptamine, Mood disorder

CLC Number: 

  • R574
[1] 中国医师协会神经内科医师分会, 中华医学会神经病学分会帕金森病及运动障碍学组,王丽娟, 等. 中国帕金森病重复经颅磁刺激治疗指南[J]. 中国神经精神疾病杂志, 2021, 47(10): 577-585. Neurophysicians Branch of Chinese Medical Association, Parkinsons Disease and Motor Disorders Group of Neurology Branch of Chinese Medical Association, WANG Lijuan, et al. Chinese guidelines for repeated transcranial magnetic stimulation in Parkinsons disease [J]. Chinese Journal of Nervous and Mental Diseases, 2021, 47(10): 577-585.
[2] Song P, Lin H, Li S, et al. Repetitive transcranial magnetic stimulation(rTMS)modulates time-varying electroencephalography(EEG)network in primary insomnia patients: a TMS-EEG study [J]. Sleep Med, 2019, 56: 157-163. doi: 10.1016/j.sleep.2019.01.007.
[3] Wu H, Lv J, Liu M, et al. The long-term effect of repetitive transcranial magnetic stimulation in the treatment of intractable insomnia [J]. Sleep Med, 2021, 85: 309-312. doi: 10.1016/j.sleep.2021.07.018.
[4] 徐建兰, 徐晓雪, 蔡青, 等. 连续多次γ-氨基丁酸和多巴胺特征重复超低频经颅磁刺激对大鼠脑内神经递质功率的影响[J]. 中国康复医学杂志, 2010, 25(2): 127-130. XU Jianlan, XU Xiaoxue, CAI Qing, et al. Effects of gamma aminobutyric acid and dopamine characteristic repetitive ultra-low frequency transcranial magnetic stimulations on rats neurotransmitter neurotransmitter power [J]. Chinese Journal of Rehabilitation Medicine, 2010, 25(2): 127-130.
[5] Chung S, Weber F, Zhong P, et al. Identification of preoptic sleep neurons using retrograde labelling and gene profiling [J]. Nature, 2017, 545(7655): 477-481.
[6] Chahine LM, Amara AW, Videnovic A. A systematic review of the literature on disorders of sleep and wakefulness in Parkinsons disease from 2005 to 2015 [J]. Sleep Med Rev, 2017, 35: 33-50. doi: 10.1016/j.smrv.2016.08.001.
[7] Hsiao YH, Chen YT, Tseng CM, et al. Sleep disorders and an increased risk of Parkinsons disease in individuals with non-apnea sleep disorders: a population-based cohort study [J]. J Sleep Res, 2017, 26(5): 623-628.
[8] 刘运洲, 张忠秋. 低频重复经颅磁刺激提高运动员睡眠质量的应用研究[J]. 中国运动医学杂志, 2012, 31(12): 1103-1106. LIU Yunzhou, ZHANG Zhongqiu. Effects of low frequency repetitive transcranial magnetic stimulation on sleep quality in athletes [J]. Chinese Journal of Sports Medicine, 2012, 31(12): 1103-1106.
[9] Falup-Pecurariu C, Diaconu ?瘙塁, ?瘙塃în?瘙塅 D, et al. Neurobiology of sleep(review)[J]. Exp Ther Med, 2021, 21(3): 272.
[10] Wilson H, Giordano B, Turkheimer FE, et al. Serotonergic dysregulation is linked to sleep problems in Parkinsons disease [J]. Neuroimage Clin, 2018, 18: 630-637. doi: 10.1016/j.nicl.2018.03.001.
[11] Feng J, Zhang Q, Zhang C, et al. The Effect of sequential bilateral low-frequency rTMS over dorsolateral prefrontal cortex on serum level of BDNF and GABA in patients with primary insomnia [J]. Brain Behav, 2019, 9(2): e01206.
[12] Jones BE. Arousal and sleep circuits [J]. Neuropsychopharmacology, 2020, 45(1): 6-20.
[13] Fort P, Bassetti CL, Luppi PH. Alternating vigilance states: new insights regarding neuronal networks and mechanisms [J]. Eur J Neurosci, 2009, 29(9): 1741-1753.
[14] 邵银进, 李海粟, 吴桂华. 超低频经颅磁刺激治疗慢性失眠的疗效[J]. 实用临床医学, 2018, 19(3): 27-29. SHAO Yinjin, LI Haisu, WU Guihua. Effects of ultra-low frequency transcranial magnetic stimulation on chronic insomnia [J]. Practical Clinical Medicine, 2018, 19(3): 27-29.
[15] Aston-Jones G, Bloom FE. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle [J]. J Neurosci, 1981, 1(8): 876-886.
[16] Wallman MJ, Gagnon D, Parent M. Serotonin innervation of human basal Ganglia [J]. Eur J Neurosci, 2011, 33(8): 1519-1532.
[17] Oikonomou G, Altermatt M, Zhang RW, et al. The serotonergic raphe promote sleep in zebrafish and mice [J]. Neuron, 2019, 103(4): 686-701.
[18] Xia M, Li Z, Li S, et al. Sleep deprivation selectively down-regulates astrocytic 5-HT2B receptors and triggers depressive-like behaviors via stimulating P2X7 receptors in mice [J]. Neurosci Bull, 2020, 36(11): 1259-1270.
[19] Keck ME, Sillaber I, Ebner K, et al. Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain [J]. Eur J Neurosci, 2000, 12(10): 3713-3720.
[20] Wilson H, Giordano B, Turkheimer FE, et al. Serotonergic dysregulation is linked to sleep problems in Parkinsons disease [J]. Neuroimage Clin, 2018, 18: 630-637. doi:10.1016/j.nicl.2018.03.001.
[21] Neikrug AB, Avanzino JA, Liu L, et al. Parkinsons disease and REM sleep behavior disorder result in increased non-motor symptoms [J]. Sleep Med, 2014, 15(8): 959-966.
[22] Zhu K, van Hilten JJ, Marinus J. The course of insomnia in Parkinsons disease [J]. Parkinsonism Relat Disord, 2016, 33: 51-57. doi: 10.1016/j.parkreldis.2016.09.010.
[23] Schür RR, Draisma LW, Wijnen JP, et al. Brain GABA levels across psychiatric disorders: a systematic literature review and meta-analysis of(1)H-MRS studies [J]. Hum Brain Mapp, 2016, 37(9): 3337-3352.
[24] Benson C, Mifflin K, Kerr B, et al. Biogenic amines and the amino acids GABA and glutamate: relationships with pain and depression [J]. Mod Trends Pharmacopsychiatry, 2015, 30: 67-79. doi:10.1159/000435933.
[25] 孙元锋, 李哲, 李韵, 等. 超低频经颅磁刺激治疗失眠症患者的疗效[J]. 实用医学杂志, 2013, 29(13): 2168-2169. SUN Yuanfeng, LI Zhe, LI Yun, et al. Effect of ultra-low frequency transcranial magnetic stimulation on insomnia patients [J]. The Journal of Practical Medicine, 2013, 29(13): 2168-2169.
[26] Baeken C, Lefaucheur JP, Van Schuerbeek P. The impact of accelerated high frequency rTMS on brain neurochemicals in treatment-resistant depression: insights from 1H MR spectroscopy [J]. Clin Neurophysiol, 2017, 128(9): 1664-1672.
[27] Ma H, Lin J, He J, et al. Effectiveness of TES and rTMS for the treatment of insomnia: meta-analysis and meta-regression of randomized sham-controlled trials [J]. Front Psychiatry, 2021, 12: 744475. doi: 10.3389/fpsyt.2021.744475.
[1] ZHANG Xiufang, LI Peizheng, ZHANG Bohan, SUN Congcong, LIU Yiming. Protective effect and mechanism of growth differentiation factor-15 in LPS-induced models of Parkinsons disease [J]. Journal of Shandong University (Health Sciences), 2022, 60(5): 1-7.
[2] ZHAO Hailong, WANG Hao, FANG Yuqing, MAO Fei, ZHAO Zhangning, TIAN Xiangqi, XU Xinrong, WANG Min, LI Xiuhua. Efficacy of additional idebenone in the treatment of 34 patients with Parkinsons disease with depression [J]. Journal of Shandong University (Health Sciences), 2022, 60(4): 38-44.
[3] LIU Liwen, MA Jun, LI Peizheng, ZHANG Xiufang, LIU Yiming. Caregiver burden and influencing factors of 128 patients with Parkinsons disease [J]. Journal of Shandong University (Health Sciences), 2022, 60(4): 45-49.
[4] LI Ning, WANG Cuilan, ZHANG Yurong. Association analysis of cerebral artery Doppler index and serum EGF level with arteriosclerosis and cognitive impairment in 60 patients with Parkinsons disease [J]. Journal of Shandong University (Health Sciences), 2021, 59(3): 61-66.
[5] LI Xiangqing, YIN Xin, ZHAO Xuelian, ZHAO Peiqing. Expression and clinical significance of circulating CD56bright subset of NK cells in patients with Parkinsons disease [J]. Journal of Shandong University (Health Sciences), 2021, 59(2): 34-40.
[6] GUO Pei, LI Xiuhua, ZHANG Xiaotao, HE Tianqi, ZHU Meijia, TANG Jiyou, ZHAO Zhangning, MAO Fei. Clinical characteristics and influencing factors of sleep disorders in patients with Parkinsons disease [J]. Journal of Shandong University (Health Sciences), 2018, 56(4): 76-80.
[7] WANG Xue-feng1, SONG Xiao1, TAN Lan2. Clinical comparison of psychotic major depression and non-psychotic major depression [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(9): 117-.
[8] LI Jia-zhen1, LIU Yi-ming1, WU Lin2, XIANG Yuan-yuan3, ZHANG Yang4, CHEN Si1, REN Nan-nan1. Impact of Madopar and Artane on depression in Parkinson′s disease in a rat model [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(11): 30-33.
[9] FU Li, WANG Yan, LI Yanzhong
. Effect of adenotonsillectomy on behavior disorders in sleepdisordered breathing children [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(02): 92-94.
[10] FU Li,WANG Yan,LI Yan-zhong. Epidemiological survey of sleep-disordered school children in the Jinan district [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(11): 1102-1104.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd