Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (12): 19-25.doi: 10.6040/j.issn.1671-7554.0.2022.0976

• 临床医学 • Previous Articles    

Efficacy of ultra-low frequency transcranial magnetic stimulation in patients with Parkinsons disease sleep disorders

TIAN Xiangqi, WANG Hao, XU Xinrong, FANG Yuqing, MAO Fei, ZHAO Zhangning, ZHAO Hailong, WU Bingyun, LI Xiuhua   

  1. Department of Neurology, The First Affiliated Hospital of Shandong First Medical University &
    Shandong Provincial Qianfoshan Hospital, Shandong Institute of Neuroimmunology, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan 250014, Shandong, China
  • Published:2022-12-01

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Abstract: Objective To observe the efficacy of ultra-low frequency transcranial magnetic stimulation(ULF-TMS)in the treatment of patients with Parkinsons disease sleep disorder(PDSD), and to explore the possible mechanism. Methods A total of 90 PDSD patients were randomly divided into gamma aminobutyric acid(GABA)group, 5-hydroxytryptamine(5-HT)group and control group, with 30 cases in each group, receiving GABA characteristic magnetic stimulation, 5-HT characteristic magnetic stimulation and sham stimulation, respectively, once a day for 35 minutes for 7 days. All patients routinely took anti-Parkinson drugs. The scores of Pittsburgh Sleep Quality Index(PSQI), Parkinsons Disease Sleep Scale(PDSS), Epworth Sleepiness Scale(ESS), Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)were monitored 1 day before treatment, 1 day and 30 days after treatment. Results There were significant differences in the time point factors, time point and group interaction of PSQI, PDSS, ESS, HAMD and HAMA scores at the three time points(P<0.001), but there were no significant differences in group factors(P>0.05). Pairwise comparison showed that in the same group, the scores of PSQI, ESS, HAMD and HAMA in the GABA and 5-HT groups decreased(P<0.05), while PDSS score increased(P<0.05)on the day 1 after treatment compared with those 1 day before treatment, but there were no significant differences in PSQI, PDSS, ESS, HAMD and HAMA scores 1 day before treatment and 30 days after treatment(P>0.05). The scores of PSQI, ESS, HAMD and HAMA in GABA and 5-HT groups were lower than those in the control group on day 1 after treatment(P<0.05), while the score of PDSS were higher(P<0.05). The scores of PSQI, PDSS, ESS, HAMD and HAMA were not significantly different 30 days after treatment(P>0.05). Conclusion ULF-TMS can improve sleep quality and mood disorder in PDSD patients in the short term.

Key words: Ultra-low frequency transcranial magnetic stimulation, Parkinsons disease, Sleep disorder, Gamma aminobutyric acid, 5-hydroxytryptamine, Mood disorder

CLC Number: 

  • R574
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