Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (3): 61-66.doi: 10.6040/j.issn.1671-7554.0.2020.1125

Previous Articles     Next Articles

Association analysis of cerebral artery Doppler index and serum EGF level with arteriosclerosis and cognitive impairment in 60 patients with Parkinsons disease

LI Ning1, WANG Cuilan2, ZHANG Yurong1   

  1. 1. Department of Neurology, The Third Hospital of Jinan, Jinan 250132, Shandong, China;
    2. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2021-04-06

PDF (PC)

152

Abstract: Objective To analyze the association of cerebral artery Doppler index and serum epidermal growth factor(EGF)level with arteriosclerosis and cognitive impairment in 60 patients with Parkinsons disease(PD). Methods A total of 60 PD patients treated during Jun. 2017 and Dec. 2019 were selected and divided into the arteriosclerosis group(n=22)and non-arteriosclerosis group(n=38). Another 60 healthy controls were enrolled as the control group. Transcranial Doppler(TCD)was performed in all subjects. Serum EGF level was measured with enzyme-linked immunosorbent assay. Cognitive status was assessed with Montreal Cognitive Assessment Scale(MoCA). The pulsatility index(PI)and resistance index(RI)of basilar artery(BA)and middle cerebral artery(MCA), and serum EGF level were compared among the groups. The correlation among the total MoCA score, Doppler index and serum EGF level was explored with Spearman analysis. Risk factors related to cognitive dysfunction of PD were analyzed with Logistic regression. Results The RI and PI of BA and MCA in the three groups were significantly different, among which the RI and PI of the sclerosis group were higher than those of the non-sclerosis group and the control group(F=5.244, 9.745, 4.674, 10.465; P=0.007, <0.001, 0.011, <0.001).There were significant differences in serum EGF levels and MoCA scores among the three groups, in which each index of the sclerosis group was significantly lower than that of the non-sclerosis group and the control group, the non-sclerosis group was significantly lower than that of the control group(F=54.289,38.788; P<0.001). Spearman correlation analysis showed that MoCA score was negatively correlated with RI and PI of BA(r=-0.402, -0.436, P<0.05), RI and PI of MCA(r=-0.422, -0.477, P<0.05), but positively correlated with serum EGF level(r=0.667, P<0.05). Univariate analysis showed that cerebral arteriosclerosis(P=0.016), RI and PI of MCA(P=0.005, P=0.003)and BA(P<0.001, P<0.001), and EGF(P<0.001)were associated with cognitive impairment(P<0.05). Binary Logistic regression analysis showed that cerebral arteriosclerosis(OR=2.361, 95%CI=1.247-3.907), RI of MCA(OR=1.988, 95%CI=1.025-3.855), PI of MCA(OR=2.489, 95%CI=1.086-5.703)and serum EGF(OR=0.312, 95%CI=0.168-0.580)were independent risk factors of cognitive dysfunction in PD patients. Conclusion PI and RI of MCA and BA as well as serum EGF level are correlated with cerebral arteriosclerosis and mild cognitive impairment in PD patients, among which PI and RI of MCA, serum EGF level and cerebral arteriosclerosis are independent risk factors of cognitive impairment in PD patients.

Key words: Parkinsons disease, Cognitive function, Cerebral arteriosclerosis, Transcranial ultrasound Doppler, Epidermal growth factor

CLC Number: 

  • R743.3
[1] 许峰, 姚晨, 李晓秋, 等. 微电极记录和宏刺激丘脑底核在脑深部电刺激术治疗帕金森病中的应用[J]. 中华神经外科杂志, 2017, 33(6): 578-581. XU Feng, YAO Chen, LI Xiaoqiu, et al. Application of microelectrode recording and macrostimulation of subthalamic nucleus in deep brain stimulation for treatment of Parkinsons disease [J]. Chinese Journal of Neurosurgery, 2017, 33(6): 578-581.
[2] Saltychev M, Bärlund E, Paltamaa J, et al. Progressive resistance training in Parkinsons disease: a systematic review and meta-analysis [J]. BMJ Open, 2016, 6(1): e008756.
[3] Alcauskas M, Galetta S. Editors note: olfaction and incident Parkinson disease in US white and black older adults [J]. Neurology, 2018, 90(20): 940-941.
[4] Iván G, Nieto A, Jesús N, et al. Mild cognitive impairment in Parkinsons disease: clustering and switching analyses in verbal fluency test [J]. J Int Neuropsychol Soc, 2017, 23(6): 1-10.
[5] 杨仁光.经颅多普勒及颈动脉超声联合应用于脑动脉硬化及脑梗死早期诊断中的临床意义[J].中国实用神经疾病杂志,2017, 20(9): 98-100. YANG Renguang. Clinical significance of transcranial Doppler and carotid ultrasound in early diagnosis of cerebral arteriosclerosis and cerebral infarction [J]. Chinese Journal of Practical Nervous Diseases, 2017, 20(9): 98-100.
[6] 叶剑虹, 容小明, 吕瑞妍, 等. 鼻咽癌放疗后放射性颞叶坏死患者的脑血管动脉硬化的临床研究[J]. 中华放射医学与防护杂志, 2018, 38(4): 273-277. YE Jianhong, RONG Xiaoming, LYU Ruiyan, et al. Study of radiation-induced cerebral vascular and carotid atherosclerosis in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis [J]. Chinese Journal of Radiological Medicine and Protection, 2018, 38(4): 273-277.
[7] 中华神经精神科杂志编委会. 脑动脉硬化症诊断标准[J]. 中华神经精神科杂志, 1988, 11(2): 128.
[8] Lim NS, Swanson CR, Cherng HR, et al. Plasma EGF and cognitive decline in Parkinsons disease and Alzheimers disease [J]. Ann Clin Transl Neurol, 2016, 3(5): 346-355.
[9] 中华医学会神经病学分会帕金森病及运动障碍学组,中国医师协会神经内科医师分会帕金森病及运动障碍专业.中国帕金森病的诊断标准(2016版)[J]. 中华神经科杂志, 2016, 49(4): 268-271.
[10] Nasreddine ZS, Phillips NA, Bédirian V, et al. The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment[J]. J Am Geriatr Soc, 2005, 53(4): 695-699.
[11] Broeders M, de Bie RM, Velseboer DC, et al. Evolution of mild cognitive impairment in Parkinson disease[J]. Neurology, 2014, 81(4): 346-352.
[12] Levin OS, Chimagomedova AS, Skripkina NA, et al. Nonmotor symptoms in vascular and other secondary parkinsonism [J]. Int Rev Neurobiol, 2017, 134(1): 1303-1334.
[13] Hao Q, Feldmann E, Balucani C, et al. A new transcranial doppler scoring system for evaluating middle cerebral artery stenosis [J]. J Neuroimaging, 2020, 30(1): 97-103.
[14] Vinciguerra L, Lanza G, Puglisi V, et al. Transcranial doppler ultrasound in vascular cognitive impairment-no dementia [J]. PLoS One, 2019, 14(4): e0216162.
[15] 李振光,于成勇,于占彩,等.血清表皮生长因子对帕金森病认知功能损害的预测价值[J].中国神经免疫学和神经病学杂志,2015,22(4):229-232. LI Zhenguang, YU Chengyong, YU Zhancai, et al. Predictive value of serum epidermal growth factor on cognitive impairment in Parkinsons disease[J].Chinese Journal of Neuroimmunology and Neurology,2015,22(4):229-232.
[16] 徐剑霞, 刘卫国, 华平,等. 帕金森病前驱期轻度认知功能障碍的临床特点及相关影响因素分析[J]. 中华神经医学杂志, 2020, 19(10):1001-1007. XU Jianxia, LIU Weiguo, HUA Ping, et al. The clinical characteristics and related influencing factors of mild cognitive impairment in the prodromal stage of Parkinsons disease[J]. Chinese Journal of Neuromedicine, 2020, 19(10):1001-1007.
[17] 荆京,孟霞,王安心, 等.多发颅内动脉粥样硬化性狭窄对轻型卒中和短暂性脑缺血发作早期卒中复发风险影响研究[J].中国卒中杂志, 2019, 14(6): 555-560. JING Jing, MENG Xia, WANG Anxin, et al. Effect of multiple intracranial atherosclerotic stenosis on the risk of recurrent stroke in patients with transient ischemic attack and minor stroke [J]. Chinese Journal of Stroke, 2019, 14(6): 555-560.
[18] 方传勤, 王娟娟, 杜艳群, 等. NIHSS/DWI-ASPECTS不匹配预测大脑中动脉供血区脑梗死早期神经功能恶化[J]. 中风与神经疾病杂志, 2019, 36(7): 628-631. FANG Chuanqin, WANG Juanjuan, DU Yanqun, et al. NIHSS/DWI-ASPECTS mismatch predicts early neurological deterioration in patients with middle cerebral artery cerebral infarction [J]. Journal of Apoplexy and Nervous Diseases, 2019, 36(7): 628-631.
[19] Jiang QW, Wang C, Zhou Y, et al. Plasma epidermal growth factor decreased in the early stage of Parkinsons disease [J]. Aging Dis, 2015, 6(3): 168-173.
[1] ZHANG Xiufang, LI Peizheng, ZHANG Bohan, SUN Congcong, LIU Yiming. Protective effect and mechanism of growth differentiation factor-15 in LPS-induced models of Parkinsons disease [J]. Journal of Shandong University (Health Sciences), 2022, 60(5): 1-7.
[2] ZHAO Hailong, WANG Hao, FANG Yuqing, MAO Fei, ZHAO Zhangning, TIAN Xiangqi, XU Xinrong, WANG Min, LI Xiuhua. Efficacy of additional idebenone in the treatment of 34 patients with Parkinsons disease with depression [J]. Journal of Shandong University (Health Sciences), 2022, 60(4): 38-44.
[3] LIU Liwen, MA Jun, LI Peizheng, ZHANG Xiufang, LIU Yiming. Caregiver burden and influencing factors of 128 patients with Parkinsons disease [J]. Journal of Shandong University (Health Sciences), 2022, 60(4): 45-49.
[4] LI Xiangqing, YIN Xin, ZHAO Xuelian, ZHAO Peiqing. Expression and clinical significance of circulating CD56bright subset of NK cells in patients with Parkinsons disease [J]. Journal of Shandong University (Health Sciences), 2021, 59(2): 34-40.
[5] YANG Xuemei, LI Juan, WANG Yifan, LI Peilong, WANG Yunshan, DU Lutao, WANG Chuanxin. Significance of a three-lncRNAs signature on the prediction of survival for HER2 positive breast cancer patients [J]. Journal of Shandong University (Health Sciences), 2020, 58(5): 69-76.
[6] SONG Limin, LU Shanshan, WANG Dawei, LÜ Xin, GAO Yuan, TANG Jiyou. Correlation between sleep architecture and attention and memory function in chronic insomniacs [J]. Journal of Shandong University (Health Sciences), 2019, 57(4): 52-58.
[7] WANG Jianli, WANG Xiaojing, SUN Yulian, HU Xiaole, LUAN Xiaorong. Clinical effect of gefitinib combined with chemotherapy on patients with advanced non-small cell lung cancer [J]. Journal of Shandong University (Health Sciences), 2019, 57(11): 20-26.
[8] XU Shuyuan, JI Quanjiang, GUO Li. Effects of serum levels of sEGFR, CEA and Cyfra21-1 on the prognosis of non-small cell lung cancer patients [J]. Journal of Shandong University (Health Sciences), 2019, 57(10): 107-111.
[9] XIE Hounai, LI Meng, XU Lin, WANG Hui, PENG Yue, PENG Zhongmin. Clinical analysis of gefitinib versus pemetrexed combined with cisplatin in patients with stage Ⅱ-ⅢA lung adenocarcinoma harbouring positive EGFR mutations [J]. Journal of Shandong University (Health Sciences), 2018, 56(9): 29-34.
[10] SHI Shuyuan, GUAN Zhiyu, SUN Daqiang. Recombinant human vascular endostatin enhances antitumour activity of EGFR-TKIs for lung cancer [J]. Journal of Shandong University (Health Sciences), 2018, 56(9): 6-10.
[11] GUO Pei, LI Xiuhua, ZHANG Xiaotao, HE Tianqi, ZHU Meijia, TANG Jiyou, ZHAO Zhangning, MAO Fei. Clinical characteristics and influencing factors of sleep disorders in patients with Parkinsons disease [J]. Journal of Shandong University (Health Sciences), 2018, 56(4): 76-80.
[12] ZHOU Dong, CHANG Hong, SUN Ruopeng. Neuroprotection of sodium pyruvate on repetitive and profound neonatal hypoglycemic brain injury [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(4): 37-42.
[13] SUN Yukai, LI Zhonghua, WANG Haiqin, LU Changhui, YANG Bo, WANG Yimin. A randomized prospective study on the clinical effect of two treatments on keloids [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(8): 85-89.
[14] YANG Li-min1,2, WANG Yan1, SUN Meng-meng2, CUI Kai-yan2, WANG Li-na2, LIU Lan-fen1,2. Information processing speed and related factors in first-episode schizophrenia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(9): 100-104.
[15] FENG Wen1, FANG Yu1, YANG Cheng-xi2. Expressions of ERCC1 and C-erbB2 in endometrial carcinoma tissue and their impact on the therapeutic effect of integrated Chinese and Western medicine [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(10): 81-84.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] ZHENG Min,HAO Yue-wei,LIU Xue-ping,ZHAO Ting-ting. Relationship between the HPA-2 and Kozak sequence polymorphism of platelet membrane glycoprotein and cerebral infarction[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(3): 292 -295 .
[2] ZHANG Jie,LI Zhen-hua,SUN Jin-hao,BAO Li-hua,LIU Yue-peng. Protective effects of the invariable magnetic field on oxidative injured Schwann cells[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(3): 229 -232 .
[3] . [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(10): 995 .
[4] JIANG Hong-ju,LI Run-zhi, WANG Ying,XU Dong-mei,ZHANG Mei,ZHANG Yun,LI Ji-fu. Relationship between the plasma level of matrix metalloproteinase-9 and structural characteristics of plaques and percutaneous coronary intervention [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(10): 966 -970 .
[5] WANG Shu-qin,QI Feng,WU Jian-bo,SUN Bao-zhu. Effect of calcium in ropivacaine-induced smooth muscle contraction of the aorta in rats in vitro[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(8): 773 -776 .
[6] TENG Xue-ren,ZHAO Yong-sheng,HU Guang-liang,ZHOU Lun,LI Jian-min. Characteristics of microcosmic changes following tendon allograft transplantation preserved by two methods under light microscopy and transmission electron microscopy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(10): 945 -950 .
[7] WU Min,ZHAO Zhi-lun,WANG Jie-zhen. [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(11): 1146 -1149 .
[8] ZHAO Peng,BI Wan-li,LI Ning. Post-processing techniques of spiral CT in adolescent congenital spinal deformity[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(8): 825 -829 .
[9] JIAO Fang-fang,LIU Shi-qing,LI Fei,LI Chang-sheng,WANG Qin,SUN Qing,LU Wei. Therapeutic effects of Huayulifei on expression of SMAD7 and TGF-β in rats with bleomycin-induced pulmonary fibrosis[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(10): 1054 -1058 .
[10] ZHAO Ying， YAN Lei， ZHANG Hui， YU Peng， LI Ming-jiang， ZHAO Xing-bo. Expression of SPAG9 in patients with serous epithelial ovarian tumors[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(2): 98 .
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd