Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (3): 61-66.doi: 10.6040/j.issn.1671-7554.0.2020.1125

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Association analysis of cerebral artery Doppler index and serum EGF level with arteriosclerosis and cognitive impairment in 60 patients with Parkinsons disease

LI Ning1, WANG Cuilan2, ZHANG Yurong1   

  1. 1. Department of Neurology, The Third Hospital of Jinan, Jinan 250132, Shandong, China;
    2. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Online:2021-03-10 Published:2021-04-06

Abstract: Objective To analyze the association of cerebral artery Doppler index and serum epidermal growth factor(EGF)level with arteriosclerosis and cognitive impairment in 60 patients with Parkinsons disease(PD). Methods A total of 60 PD patients treated during Jun. 2017 and Dec. 2019 were selected and divided into the arteriosclerosis group(n=22)and non-arteriosclerosis group(n=38). Another 60 healthy controls were enrolled as the control group. Transcranial Doppler(TCD)was performed in all subjects. Serum EGF level was measured with enzyme-linked immunosorbent assay. Cognitive status was assessed with Montreal Cognitive Assessment Scale(MoCA). The pulsatility index(PI)and resistance index(RI)of basilar artery(BA)and middle cerebral artery(MCA), and serum EGF level were compared among the groups. The correlation among the total MoCA score, Doppler index and serum EGF level was explored with Spearman analysis. Risk factors related to cognitive dysfunction of PD were analyzed with Logistic regression. Results The RI and PI of BA and MCA in the three groups were significantly different, among which the RI and PI of the sclerosis group were higher than those of the non-sclerosis group and the control group(F=5.244, 9.745, 4.674, 10.465; P=0.007, <0.001, 0.011, <0.001).There were significant differences in serum EGF levels and MoCA scores among the three groups, in which each index of the sclerosis group was significantly lower than that of the non-sclerosis group and the control group, the non-sclerosis group was significantly lower than that of the control group(F=54.289,38.788; P<0.001). Spearman correlation analysis showed that MoCA score was negatively correlated with RI and PI of BA(r=-0.402, -0.436, P<0.05), RI and PI of MCA(r=-0.422, -0.477, P<0.05), but positively correlated with serum EGF level(r=0.667, P<0.05). Univariate analysis showed that cerebral arteriosclerosis(P=0.016), RI and PI of MCA(P=0.005, P=0.003)and BA(P<0.001, P<0.001), and EGF(P<0.001)were associated with cognitive impairment(P<0.05). Binary Logistic regression analysis showed that cerebral arteriosclerosis(OR=2.361, 95%CI=1.247-3.907), RI of MCA(OR=1.988, 95%CI=1.025-3.855), PI of MCA(OR=2.489, 95%CI=1.086-5.703)and serum EGF(OR=0.312, 95%CI=0.168-0.580)were independent risk factors of cognitive dysfunction in PD patients. Conclusion PI and RI of MCA and BA as well as serum EGF level are correlated with cerebral arteriosclerosis and mild cognitive impairment in PD patients, among which PI and RI of MCA, serum EGF level and cerebral arteriosclerosis are independent risk factors of cognitive impairment in PD patients.

Key words: Parkinsons disease, Cognitive function, Cerebral arteriosclerosis, Transcranial ultrasound Doppler, Epidermal growth factor

CLC Number: 

  • R743.3
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