Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (4): 52-58.doi: 10.6040/j.issn.1671-7554.0.2018.452

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Correlation between sleep architecture and attention and memory function in chronic insomniacs

SONG Limin1,2, LU Shanshan2, WANG Dawei3, LÜ Xin2, GAO Yuan1,2, TANG Jiyou2   

  1. 1. Department of Postgraduate, Taishan Medical University, Taian 270000, Shandong, China;
    2.Department of Neurology, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong, China;
    3. Department of Medical Imaging, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the correlation between sleep architecture and attention and memory function in chronic insomniacs. Methods A total of 31 patients with chronic insomnia disorder and 26 good sleepers were enrolled in this study. All subjects were assessed with Pittsburgh Sleep Quality Index(PSQI), Epworth Sleepiness Scale(ESS), Insomnia Severity Index(ISI)and polysomnography(PSG)to evaluate sleep quality, the severity of insomnia and sleep architecture. Attention and memory functions were detected with the Wechsler Memory Scale(WMS). Results Compared with good sleepers, chronic insomniacs had higher scores of PSQI, ESS and ISI. They showed longer sleep latency, higher percentages of non-rapid eye movement sleep 1 stage(NREM1%)and non-rapid eye movement sleep 2 stage(NREM2%), and more times of wake after sleep onset(WASO), but lower percentage of non-rapid eye movement 山 东 大 学 学 报 (医 学 版)57卷4期 -宋立敏,等.慢性失眠患者睡眠结构与注意力、记忆的相关性 \=-sleep 3 stage(NREM3%)(all P<0.05). In chronic insomniacs, the worsened attention could be seen from the intelligence test and visual memory span tests; the loss of short-time memory could be detected with associative learning and logical memory tasks. Multivariate Logistic regression analysis indicated that PSQI was correlated with intelligence and visual memory(P<0.05), NREM1% was correlated with associative learning and logical memory(P<0.05), and NREM3% was correlated with logical memory(P<0.01). Conclusion The sleep architecture is disordered in chronic insomniacs. The losses of attention and short-time memory are primarily correlated with PSQI score, increased NREM1% and decreased NREM3%.

Key words: Chronic insomnia disorder, Cognitive function, Attention, Memory, Polysomnography

CLC Number: 

  • R741
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