Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (3): 85-90.doi: 10.6040/j.issn.1671-7554.0.2017.1040

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Association between basophils percentage and chronic kidney disease: a retrospective cohort study

ZHOU Miao1,2, BIAN Weiwei1,2, LIU Xiaojuan1,2, KANG Fengling1,2, XUE Fuzhong1,2, LIU Jing1,2   

  1. 1. Department of Biostatistics, School of Public Health;
    2. Cheeloo Research Center for Biomedical Big Data, Shandong University, Jinan 250012, Shandong, China
  • Received:2017-10-26 Published:2022-09-27

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Abstract: Objective To explore the effect of basophils percentage on the incidence of chronic kidney disease(CKD). Methods A retrospective cohort was conducted using the data from Shandong Multi-center Longitudinal Cohort for Health Management. All subjects ≥20 years old who were free of CKD at baseline and accepted at least two annually physical examinations were selected. The participants were divided into four groups(denoted by Q1, Q2, Q3, Q4)according to quartiles of basophils percentage at baseline. Cox regression models were used to identify the association between basophils percentage and CKD. Results The cohort consisted of 17 173 subjects, including 10 614 males and 6 559 females. There were 737 CKD cases occurring during the 42 204.04 person-years following up, resulting in an incidence of 17.46/1 000 person-year. The multivariate Cox regression model with adjusting age and gender showed that HRs(95%CI)of basophils percentage to CKD for the groups of Q2, Q3 and Q4(with Q1 as reference group)were 0.990(0.776-1.263), 1.235(1.011-1.509)and 1.352(1.099-1.663)respectively. Furthermore, after all other related variables such as body mass index, hypertension, diabetes, blood uric acid, serum creatinine, blood urea nitrogen, total cholesterol, low density lipoprotein cholesterol and triglyceride were adjusted, the HRs(95%CI)of Q2, Q3 and Q4 山 东 大 学 学 报 (医 学 版)56卷3期 -周苗,等.嗜碱性粒细胞百分比与慢性肾脏病关系的回顾性队列研究 \=-were 0.966(0.740-1.262), 1.225(0.985-1.525)and 1.355(1.077-1.705), respectively. Conclusion Increasing basophils percentage is an independent risk factor of CKD.

Key words: Chronic kidney disease, Basophils percentage, Cohort, Cox regression, Health management population

CLC Number: 

  • R692
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