山东大学学报 (医学版) ›› 2019, Vol. 57 ›› Issue (6): 81-86.doi: 10.6040/j.issn.1671-7554.0.2018.1481
• 临床医学 • 上一篇
陈红艳1,马园园2,孙虎魁2
CHEN Hongyan1, MA Yuanyuan2, SUN Hukui2
摘要: 目的 运用Meta分析方法综合评价肺癌患者PET/CT检查18F-FDG摄取(FDG-PET)定量参数SUVmax值与肿瘤程序性死亡受体-配体1(PD-L1)表达的相关性。 方法 检索 PubMed、Medline、Cochrane图书馆、中国知网、万方数据库收录的 2000年1月至2018年12月公开发表的关于肺癌患者PET/CT扫描后肿瘤局部摄取18F-FDG定量参数SUVmax值与肿瘤PD-L1表达相关性的中英文文献,提取文献中的相关系数(r值)及相关数据,使用Comprehensive Meta-Analysis软件进行Meta分析。使用Jadad量表对纳入的文献进行质量评估。 结果 共4篇文献符合纳入标准,均为英文SCI文献,样本量共1 033例。Meta分析结果显示,通过合并Spearman相关系数(r值)进行分析,SUVmax值与PD-L1表达呈弱正相关(r=0.289,95%CI:0.100~0.459,P<0.001)。亚组分析显示鳞癌和腺癌(非小细胞肺癌)均呈现相似的弱正相关趋势(r=0.235, P=0.011; r=0.273, P=0.003),均有统计学意义。 结论 肺癌摄取FDG的SUVmax值与PD-L1表达呈正相关性,鳞癌和腺癌均呈现相同趋势;FDG-PET定量参数SUVmax值可以为临床PD-1靶向治疗筛选患者和判断预后提供一定的影像学依据。
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