山东大学学报 (医学版) ›› 2019, Vol. 57 ›› Issue (2): 110-116.doi: 10.6040/j.issn.1671-7554.0.2018.1426
• 公共卫生与管理学 • 上一篇
殷晓霖1,杨孝荣2,张同超1,满金宇1,吕明1,2
YIN Xiaolin1, YANG Xiaorong2, ZHANG Tongchao1, MAN Jinyu1, LÜ Ming1,2
摘要: 目的 探讨儿茶酚氧位甲基转移酶(COMT)基因G1947A多态性与吸烟行为之间的关系。 方法 检索自建库至2018年11月PubMed,EMBASE,Web of Science和Cochrane Library数据库,严格按照纳入和排除标准筛选文献。进行Meta分析计算组合效应值及其95%可信区间(CI)。进行亚组分析探讨性别和种族之间的差异。 结果 最终纳入文献16篇,其中包括7565名当前吸烟者、6 491名已经戒烟者、9 370名从未吸烟者、14 535名吸过烟者和16 140名当前不吸烟者。在显性模型中发现,COMT基因G1947A中的等位基因A可以降低总体人群吸过烟的风险(OR=0.92,95% CI=0.85~0.98,P=0.014),尤其是亚洲人群(OR=0.77,95% CI=0.62~0.93,P=0.025)。COMT基因G1947A多态性与目前是否吸烟和戒烟状态的关系在3种模型中均无显著差异(P>0.05)。敏感性分析、影响性分析对现有结果无实质影响,且没有检测到发表偏倚。 结论 COMT基因G1947A中的A等位基因对总体人群初始不吸烟具有保护作用。
中图分类号:
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