抗氧化碳点纳米酶调控神经再生微环境的研究进展

doi:10.6040/j.issn.1671-7554.0.2024.0677

摘要/Abstract

摘要： 碳点作为一种新兴的零维光致发光纳米材料,因其制备简便、光学性质易于调控、光化学稳定性高、光电性能优异、毒性低、生物相容性好等优势,在生物医学、传感器、光电器件等方面具有广阔的应用前景。随着研究的不断深入,多种碳点被陆续报道表现出优异的类酶催化活性(碳点纳米酶),并可用于调节病理氧化还原微环境以实现高效疾病治疗。为了阐明碳点纳米酶在神经科学中的独特优势及潜在前景,本文首先介绍了碳点的抗氧化能力及活性来源,然后讨论了碳点的抗菌活性及作用机制,最后总结了抗氧化碳点纳米酶调控神经再生微环境的进展,并在此基础上展望了未来研究中如何更有效地利用碳点纳米酶的调控能力,通过精确干预病理微环境,从而加强神经组织的再生与修复。

关键词: 碳点纳米酶, 中枢神经系统, 微环境, 神经再生, 氧化应激

Abstract: Carbon dot, as an emerging zero-dimensional photoluminescent nanomaterial, has broad application prospects in biomedicine, sensors, and optoelectronic devices due to their simple preparation, easy regulation of optical properties, high photochemical stability, excellent photoelectric properties, low toxicity, and good biocompatibility. With the research deepening, a variety of carbon dots have been successively reported to exhibit excellent enzyme-like catalytic activity(carbon dot nanozymes), and can be used to regulate the pathological redox microenvironment for efficient disease treatment. To elucidate the unique advantages and potential prospects of carbon dot nanozymes in neuroscience, in this review, we firstly introduced the antioxidant capacity and the activity source of carbon dots, and then discussed the antimicrobial activity and their corresponding action mechanisms. Finally, we summarized the recent progress of antioxidant carbon-dot nanozymes in regulating the neuro-regeneration microenvironment, and further proposed the prospect of carbon dot-based modulation of pathological microenvironment for nerve regeneration.

Key words: Carbon dot nanozymes, Central nervous system, Microenvironment, Neuro-regeneration, Oxidative stress

中图分类号:

R681.5

于昊志,史桂东,徐国鹏,姜云鹏,冯世庆,刘新宇,祁磊. 抗氧化碳点纳米酶调控神经再生微环境的研究进展[J]. 山东大学学报 (医学版), 2026, 64(2): 44-49.

YU Haozhi, SHI Guidong, XU Guopeng, JIANG Yunpeng, FENG Shiqing, LIU Xinyu, QI Lei. Research progress of antioxidant carbon dot nanozymes to regulate the neuro-regeneration microenvironment[J]. Journal of Shandong University (Health Sciences), 2026, 64(2): 44-49.

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