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山东大学学报 (医学版) ›› 2025, Vol. 63 ›› Issue (2): 118-124.doi: 10.6040/j.issn.1671-7554.0.2024.1140

• 综述 • 上一篇    

氧化应激在创伤性脑损伤诱发急性肺损伤中的研究进展

李响,张艺,王雪纯,徐梦超,王月兰   

  1. 山东大学附属省立医院麻醉科, 山东 济南 250021
  • 出版日期:2025-03-10 发布日期:2025-03-07
  • 通讯作者: 王月兰. E-mail:LXQ9066@163.com
  • 基金资助:
    国家自然科学基金(82070078)

Research progress on oxidative stress in acute lung injury induced by traumatic brain injury

LI Xiang, ZHANG Yi, WANG Xuechun, XU Mengchao, WANG Yuelan   

  1. Department of Anesthesiology, Shandong Provincial Hospital, Shandong University, Jinan 250021, Shandong, China
  • Online:2025-03-10 Published:2025-03-07

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摘要： 创伤性脑损伤是全球性的重大公共健康问题,其诱发的急性肺损伤日益引起重视。创伤性脑损伤诱发的急性肺损伤是一个多因素、多机制的复杂病理状态,其有效管理要求对创伤性脑损伤和急性肺损伤之间的相互作用有深入理解。本文从氧化应激诱发肺泡-毛细血管屏障损害、肺部炎症以及加重凝血功能障碍三个方面对创伤性脑损伤诱发急性肺损伤的研究进展进行总结;同时探讨右美托咪定、胃泌素、虎杖苷以及伊诺肝素等药物的潜在治疗作用,为临床预防和治疗创伤性脑损伤诱发的急性肺损伤提供研究基础和理论指导。

关键词: 创伤性脑损伤, 急性肺损伤, 氧化应激, 肺泡-毛细血管屏障, 细胞凋亡

Abstract: Traumatic brain injury represents a significant global public health concern, with its associated acute lung injury gaining increased attention. The pathogenesis of acute lung injury induced by traumatic brain injury is complex, involving multiple factors and mechanisms. Effective management requires a comprehensive understanding of the interplay between traumatic brain injury and acute lung injury. This article summarizes recent advances in understanding how oxidative stress induces damage to the alveolar-capillary barrier, as well as its role in promoting pulmonary inflammation and exacerbating coagulation dysfunction in acute lung injury induced by traumatic brain injury. Additionally, it explores the potential therapeutic effects of agents such as dexmedetomidine, gastrin, polydatin, and enoxaparin, providing a foundation for future clinical strategies aimed at the prevention and treatment of acute lung injury induced by traumatic brain injury. These insights offer valuable theoretical guidance for clinicians in improving patient outcomes.

Key words: Traumatic brain injury, Acute lung injury, Oxidative stress, Alveolar-capillary barrier, Apoptosis

中图分类号: 

  • R563
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