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山东大学学报（医学版） ›› 2015, Vol. 53 ›› Issue (7): 39-42.doi: 10.6040/j.issn.1671-7554.0.2015.069

• 临床医学 • 上一篇    下一篇

Netrin-1在乳腺浸润性导管癌中的表达及与转移的相关性

高永生1, 王春健2, 蔡淑萍1, 孙菊杰1, 张德贤1, 孙妍琳3, 穆殿斌1   

  1. 1. 山东省肿瘤医院病理科, 山东 济南 250117;
    2. 山东省肿瘤医院乳腺外科, 山东 济南 250117;
    3. 山东大学医学院病理学教研室, 山东 济南 250012
  • 收稿日期:2015-01-16 修回日期:2015-05-19 出版日期:2015-07-10 发布日期:2015-07-10
  • 通讯作者: 穆殿斌。E-mail:mudbin@163.com;孙妍琳。E-mail:yanlinsunny@sdu.edu.cn E-mail:mudbin@163.com;yanlinsunny@sdu.edu.cn
  • 基金资助:
    国家自然科学基金(81101672)

Expression of netrin-1 in invasive ductal breast cancer and its relationship with tumor metastasis

GAO Yongsheng1, WANG Chunjian2, CAI Shuping1, SUN Jujie1, ZHANG Dexian1, SUN Yanlin3, MU Dianbin1   

  1. 1. Department of Pathology, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong, China;
    2. Department of Breast Surgery, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong, China;
    3. Department of Pathology, Medical College of Shandong University, Jinan 250012, Shandong, China
  • Received:2015-01-16 Revised:2015-05-19 Online:2015-07-10 Published:2015-07-10

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摘要： 目的 探讨Netrin-1蛋白在乳腺浸润性导管癌中的表达及临床意义。方法 采用免疫组织化学SP法检测46例乳腺浸润性导管癌中Netrin-1的表达。结果 46例乳腺浸润性导管癌中30例表达阳性, 16例表达阴性。Netrin-1在有淋巴结转移中的阳性率为78.6%(11/14)。Netrin-1的表达与乳腺癌患者的年龄、原发肿瘤的大小、临床分期及雌激素受体、孕激素受体、Her-2和KI-67的表达无关(P均>0.05), 但与肿瘤的转移有明显的相关性(P<0.05)。结论 乳腺癌患者中存在Netrin-1的异常表达, Netrin-1可能在乳腺癌的发生及转移过程中起到重要作用, Netrin-1可单独作为一个预测乳腺癌转移的指标。

关键词: Netrin-1蛋白, 腋窝淋巴结, 转移, 乳腺肿瘤

Abstract: Objective To investigate the expression of netrin-1 in invasive ductal breast cancer and its clinical significance. Methods The expression of netrin-1 in 46 cases of invasive ductal breast cancer was detected with immunohistochemical SP method. Results Of all 46 cases, 30 cases had positive and 16 cases had negative expression of netrin-1. The positive rate of netrin-1 expression was 78.6% (11/14) in the group of breast cancer with lymph node metastasis. The expression of netrin-1 was not related to the patients' age, tumor size, clinical stage, expression of ER, PR, Her-2 and KI-67 (P>0.05), but was closely related to tumor metastasis (P<0.05). Conclusion Netrin-1 is abnormally expressed in breast cancer. It probably plays an important role in tumorigenesis and metastasis of breast cancer, and may be used as a marker for the prediction of breast cancer metastasis.

Key words: Breast neoplasm, Axillary lymph node, Netrin-1 protein, Metastasis

中图分类号: 

  • R736.1
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