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山东大学学报(医学版) ›› 2015, Vol. 53 ›› Issue (7): 34-38.doi: 10.6040/j.issn.1671-7554.0.2014.933

• 临床医学 • 上一篇    下一篇

术中冰冻病理对乳腺导管内乳头状肿瘤的诊断价值

代高赛, 马婷婷, 江立玉, 霍强, 孔晓丽, 景楚瑜, 杨其峰   

  1. 山东大学齐鲁医院乳腺外科, 山东 济南 250012
  • 收稿日期:2014-12-10 修回日期:2015-03-13 出版日期:2015-07-10 发布日期:2015-07-10
  • 通讯作者: 杨其峰。E-mail:qifengy@gmail.com E-mail:qifengy@gmail.com

Diagnostic value of frozen section for breast intraductal papillary neoplasms

DAI Gaosai, MA Tingting, JIANG Liyu, HUO Qiang, KONG Xiaoli, JING Chuyu, YANG Qifeng   

  1. Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-12-10 Revised:2015-03-13 Online:2015-07-10 Published:2015-07-10

摘要: 目的 探讨术中冰冻病理对乳腺导管内乳头状肿瘤(IDPN)的诊断价值及相关影响因素。方法 对2007年1月至2013年12月收治的560例术后石蜡病理确诊为乳腺IDPN的患者进行回顾性分析, 对比术中冰冻病理与术后石蜡病理结果, 观察术中冰冻病理诊断准确率及其相关影响因素。结果 ① 术中冰冻病理对于IDPN总体诊断准确率为85.1%,其中导管内乳头状瘤与导管内乳头状癌诊断准确率分别为88.9%、49.0%, 差异有统计学意义(P<0.05);② 16例(3.1%)患者诊断病理级别升高, 1例(0.2%)患者诊断病理级别降低;③ 伴有及不伴有乳头溢液患者诊断准确率分别为89.2%、79.4%, 差异有统计学意义(P<0.05)。结论 术中冰冻病理对于诊断IDPN意义重大, 导管内乳头状瘤诊断准确率高于导管内乳头状癌, 伴有乳头溢液患者比不伴有者术中冰冻病理诊断准确率高。

关键词: 导管内乳头状肿瘤, 乳头溢液, 石蜡病理, 冰冻病理

Abstract: Objective To investigate the significance of intraoperative frozen section in the diagnosis of intraductal papillary neoplasms and influencing factors. Methods Clinical data of 560 patients with intraductal papillary neoplasms confirmed with postoperative paraffin pathology in the Department of Breast Surgery, Qilu Hospital of Shandong University during Jan. 2007 to Dec. 2013 were retrospectively analyzed. The results of intraoperative frozen sections and postoperative paraffin sections were compared and factors affecting diagnostic accuracy rate were studied. Results The overall accuracy rate of intraoperative frozen sections was 85.1%. The accuracy rate of intraductal papilloma and intraductal papillary carcinoma was 88.9% and 49.0%, respectively (P<0.05). Of all patients, 16 cases (3.1%) with higher and 1 case (0.2%) with lower pathological grade were observed. The accuracy rate with and without nipple discharge was 89.2% and 79.4%, respectively (P<0.05). Conclusion Intraoperative frozen section can yield high accuracy for the diagnosis of intraductal papillary neoplasms. The accuracy rate of intraductal papilloma is higher than that of intraductal papillary carcinoma, and the accuracy rate is higher in patients with nipple discharge than those without.

Key words: Intraductal papillary neoplasms, Paraffin section, Frozen section, Nipple discharge

中图分类号: 

  • R655.8
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