山东大学学报(医学版) ›› 2015, Vol. 53 ›› Issue (7): 43-47.doi: 10.6040/j.issn.1671-7554.0.2014.964
田馨莉1, 矫俊1, 张腾1, 马道新2, 崔保霞1
TIAN Xinli1, JIAO Jun1, ZHANG Teng1, MA Daoxin2, CUI Baoxia1
摘要: 目的 探讨宫颈癌外周血中Th22细胞和Th17细胞的表达及其在宫颈癌发生发展中的作用。方法 取34例宫颈癌患者外周血为宫颈癌组、21例宫颈上皮内瘤变(CIN)患者的外周血为CIN组、19例健康志愿者外周血为对照组, 采用流式细胞术检测外周血中Th22、Th17细胞的表达比例。酶联免疫吸附试验(ELISA) 方法检测血浆中相关细胞因子白细胞介素-22(IL-22)的水平。结果 与对照组比较, Th22、Th17细胞比例(占淋巴细胞百分比)CIN组(P<0.01, P<0.05) 及宫颈癌组(P<0.01, P<0.01)均明显升高。Th22细胞比例宫颈癌组又明显高于CIN组(P<0.01)。CIN组中Th22细胞与Th17细胞呈正相关(r=0.41, P<0.05 ), 宫颈癌组Th22细胞与Th17细胞呈正相关(r=0.49, P<0.01)。与对照组相比, IL-22在宫颈癌组外周血中明显升高(P<0.05)。结论 Th22、Th17细胞在宫颈癌患者外周血中比例增高, 在宫颈癌的发生发展中可能起着重要作用。
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