山东大学学报 (医学版) ›› 2018, Vol. 56 ›› Issue (11): 18-26.doi: 10.6040/j.issn.1671-7554.0.2018.692
• • 上一篇
吴卫东1,安珍1,2,贵双俊3,许洁1,范威1,宋杰1
WU Weidong1, AN Zhen1,2, GUI Shuangjun3, XU Jie1, FAN Wei1, SONG Jie1
摘要: 细颗粒物(PM2.5)是指大气中空气动力学直径 ≤ 2.5 μm的颗粒物,是雾霾的重要成因,也是大气中对人体危害较大的组分之一。流行病学调查、临床研究以及毒理学实验结果显示,PM2.5与心血管疾病的发生发展密切相关。短期PM2.5暴露可促发急性心血管事件,长期暴露则大幅度增加心血管疾病的发病风险和死亡风险。近几十年心血管疾病始终是全球首要的致死原因,而动脉粥样硬化(AS)是心血管疾病的主要病理基础。流行病调查研究和动物实验均发现,短期暴露高浓度或长期暴露低浓度PM2.5可促进AS的进展,引起不稳定性斑块破裂,但潜在机制尚未阐明。就PM2.5暴露与AS加剧之间的关系,以及PM2.5暴露造成AS加剧的潜在机制研究现状进行综述。
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