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    Advances in Basic and Clinical Research on Aortic Diseases-Expert Commentary
    Current status and reflections on the treatment of aortic disease
    CHEN Zhong, WANG Sheng
    Journal of Shandong University (Health Sciences). 2024, 62(9):  1-6.  doi:10.6040/j.issn.1671-7554.0.2024.0774
    Abstract ( 216 )   PDF (844KB) ( 137 )   Save
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    Aortic aneurysm and aortic dissection are common diseases in vascular surgery. With the development of endovascular technology, the treatment of aortic diseases has entered a brand-new stage. Due to the different anatomical conditions and hemodynamic characteristics of lesions in different parts of aorta, the difficulties and solutions are also different. Therefore, this article reviews the difficulties and solutions for aortic aneurysm and aortic dissection at different anatomical sites. Regarding endovascular treatment of aneurysms or dissection in the ascending aorta, the difficulty lies in the large variation in the diameter of the aortic during systole and diastole, which makes anchoring difficult. On the other hand, there is a lack of suitable stents for patients with a short anchoring zone. In aortic arch disease, branch stenting or fenestration techniques have achieved overall satisfactory results, but there are still limitations in the occurrence of neurological complications due to high technical difficulty and positive correlation with the number of branches of the stent. Additionally, the in situ or pre-opening stenting technique may have potential impacts on the long-term treatment of aortic disease, which needs to been further observed. For lesions involving the thoracic and abdominal aorta, the difficulty lies in the presence of a large number of visceral branch vessels and the complication of endovascular fistulas after stenting. Relevant branch stents have already entered the stage of multicenter clinical trials, and their long-term results need to be observed. For patients whose anatomical conditions do not meet the requirements of endovascular treatment, open surgery remains a reliable method, if systemic conditions allow. Therefore, for future endovascular treatment of aortic aneurysm and aortic dissection, more flexibal stents are needed first; additionauy, vascular surgeons should strictly follow the indications and carefully select the endovascular treatment.
    Advances in Basic and Clinical Research on Aortic Diseases-Research Progress
    Progress in diagnosis and treatment of Stanford type B aortic dissection
    LIN Changpo, FU Weiguo
    Journal of Shandong University (Health Sciences). 2024, 62(9):  7-12.  doi:10.6040/j.issn.1671-7554.0.2024.0448
    Abstract ( 211 )   PDF (1661KB) ( 121 )   Save
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    The diagnosis and treatment of Stanford type B aortic dissection(TBAD)has been greatly improved in recent years due to a better understanding of the disease. On one hand, the classification of TBAD has been more refined, thus enabling better guidance for AD diagnosis and treatment. On the other hand, the using of new imaging tests and biomarkers has helped to further improve the accuracy of AD diagnosis. In terms of treatment, along with the rapid development of endovascular technology, the treatment of TBAD tends to be minimally invasive, and the result is also significantly improved. Endovascular therapy of TBAD involving aortic arch or visceral areas is a hot topic nowadays, and many new methods and devices have emerged in this areas, which are expected to further improve the clinical outcome.
    Current status of endovascular therapy for abdominal aortic aneurysm
    WEI Ren, GUO Wei
    Journal of Shandong University (Health Sciences). 2024, 62(9):  13-18.  doi:10.6040/j.issn.1671-7554.0.2024.0305
    Abstract ( 150 )   PDF (845KB) ( 76 )   Save
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    Endovascular repair has become the preferred strategy for the treatment of abdominal aortic aneurysm(AAA). In recent years, endovascular technology has developed rapidly, and innovative techniques represented by "fenestration", "chimney", and branch technology have emerged to address different types of AAA. Based on these techniques, many new types of off-the-shelf stents have also been designed. This article provides a review of the current status of endovascular repair for different anatomical types of AAA from the perspectives of technical aspects, evidence-based medicine, and clinical guidelines. It also addresses the highly concerning issue of complications.
    Advances in diagnosis and treatment of traumatic type B aortic dissection
    WANG Lunchang, QIN Qi, SHU Chang
    Journal of Shandong University (Health Sciences). 2024, 62(9):  19-25.  doi:10.6040/j.issn.1671-7554.0.2024.0295
    Abstract ( 140 )   PDF (876KB) ( 74 )   Save
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    This article focuses on the clinical research advancements in traumatic type B aortic dissection(TTBAD), and summarized its pathogenesis, clinical features and diagnosis, severity classification, treatment modalities, and follow-up prognosis. TTBAD is commonly observed in patients with multiple trauma injuries, and making early and accurate diagnosis is imperative. The severity of the injury is a critical determinant in deciding the treatment strategy and prognosis for TTBAD patients. Treatment emphasizes a multidisciplinary approach, with pharmacotherapy and thoracic endovascular aortic repair(TEVAR)being the primary options. However, there remains some controversy regarding treatment strategies and the timing of surgery in patients with varying severities of TTBAD.
    Open aortic repair of abdominal aortic aneurysm
    SHI Xiaoxi, XIN Shijie
    Journal of Shandong University (Health Sciences). 2024, 62(9):  26-29.  doi:10.6040/j.issn.1671-7554.0.2024.0341
    Abstract ( 146 )   PDF (837KB) ( 52 )   Save
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    Abdominal aortic aneurysm(AAA)is a common disease in vascular surgery. Traditional open aortic repair(OAR)or endovascular aortic repair(EVAR)is the only effective treatment. OAR reached its peak between 1950s and 1990s, and due to its trauma, technical complexity and the rapid development of EVAR technology, the application of OAR has gradually decreased. However, the role of OAR is still irreplaceable in basic research, young patients and mycotic AAA. This study reviewed the history and current situation of OAR, analyzed its advantages and disadvantages, discussed the key points of intraoperative techniques and the management of complications, and summarized the role and position played by OAR in the EVAR era.
    Progress in diagnosis and treatment of immune disease related aortic lesions
    GAO Jianfeng, LI Fangda, WU Lianglin, ZENG Rong, ZHENG Yuehong
    Journal of Shandong University (Health Sciences). 2024, 62(9):  30-35.  doi:10.6040/j.issn.1671-7554.0.2024.0375
    Abstract ( 179 )   PDF (835KB) ( 70 )   Save
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    Immune-related aortic disease has always been a challenging lesion in vascular surgery, characterized by obstructive or dilated lesions in the aorta, leading to ischemia of organs and limbs, as well as the high mortality risk from aneurysm rupture. Previously, there was a lack of specificity in the diagnosis of the immune diseases that cause such aortic lesions, which may result in deficiencies in the comprehensive management of the disease. With the development of medical science, the management of this disease has been significantly improved, but its research progress still needs to be systematically summarized. This review aims to conclude the current status of the management for common immune-related aortic diseases(Takayasus aortitis, giant cell arteritis, Behcets arteritis)from diagnosis and therapy perspectives, and to provide recommendations for different types of aortic lesions, as well as to guide clinical work and future development in this field.
    Advances in diagnosis and treatment of blunt thoracic aortic injury
    YANG Jianping, GUAN Sheng, FANG Qingbo, CI Hongbo, GE Xiaohu
    Journal of Shandong University (Health Sciences). 2024, 62(9):  36-41.  doi:10.6040/j.issn.1671-7554.0.2024.0319
    Abstract ( 127 )   PDF (849KB) ( 36 )   Save
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    Blunt thoracic aortic injury(BTAI)is the major cause of morbidity and mortality in trauma patients, with 80%-90% of patients dying immediately at the scene of the accident. Despite rapid advances in the detection and treatment of acute BTAI in recent years, the mortality rate remains high, with a mortality rate of 15%-40% of in-hospital deaths within 24 hours. The mechanism of aortic injury is related to physical impact and drastic changes in hemodynamics. For patients who survive the initial injury, maintaining hemodynamic stability in time may prevent injury exacerbation. For patients who can reach the hospital, rapid detection and timely and reasonable intervention are crucial. CT angiography can quickly and accurately evaluate the degree of aortic injury and guide the reasonable treatment measures. According to the latest guidelines, the time and method of treatment for grade Ⅰ, Ⅲ and Ⅳ patients have been clearly defined. But repair time in grade Ⅱ patients with BTAI combined with high-risk imaging features is still controversial. Thoracic endovascular aortic repair due to high clinical success rate and low complication rate has become the preferred method for BTAI, but there are still some unavoidable focal problems. This article mainly reviewed the injury mechanism, clinical manifestations, imaging diagnosis and treatment of BTAI.
    Progress in diagnosis and treatment of infective native aortic aneurysm
    HUO Zhengkun, KONG Xiangqian, WU Xuejun
    Journal of Shandong University (Health Sciences). 2024, 62(9):  42-48.  doi:10.6040/j.issn.1671-7554.0.2024.0323
    Abstract ( 169 )   PDF (2679KB) ( 122 )   Save
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    Infective native aortic aneurysm(INAA)is a rare and highly lethal disease in the field of vascular surgery, caused by degeneration and destruction of the aortic wall with the microorganism(mostly by bacteria). INAA has rapid progress, complicated symptoms, high rupture risk and poor prognosis. The diagnosis and treatment of INAA remain foci and challenges in vascular surgery. This review discussed the etiology, pathogenesis, clinical symptoms, diagnosis, treatment and complications of INAA based on the published papers and our management experiences, in order to provide advice to the future research and managements.
    Progress in spinal cord protection strategies for open repair of thoracoabdominal aortic aneurysms
    ZHOU Yongkang, SUN Jing, ZHANG Shuai, QIAN Xiangyang
    Journal of Shandong University (Health Sciences). 2024, 62(9):  49-54.  doi:10.6040/j.issn.1671-7554.0.2024.0308
    Abstract ( 150 )   PDF (839KB) ( 83 )   Save
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    Thoracoabdominal aortic aneurysm(TAAA)is an extremely dangerous disease, and open surgery has been the gold standard for its treatment. In the past decades, despite significant advances in surgical techniques and adjuncts, the incidence of perioperative complications has remained high due to the lengthy and traumatic nature of open repair surgery for TAAA. Spinal cord injury is one of the most serious complications, which usually lead to unacceptable outcomes such as paraplegia and paraparesis of lower limbs. Therefore, the perioperative spinal cord protection strategies in open repair of TAAA have been the focus of scholars research. This review discussed the research progress of spinal cord protection strategies in open repair of TAAA.
    Progress in prevention and treatment of type Ⅱ endoleak after endovascular abdominal aortic aneurysm repair
    FAN Libin, ZHANG Hongkun
    Journal of Shandong University (Health Sciences). 2024, 62(9):  55-60.  doi:10.6040/j.issn.1671-7554.0.2024.0271
    Abstract ( 156 )   PDF (851KB) ( 41 )   Save
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    Abdominal aortic aneurysm(AAA)is a life-threatening disease and its incidence is increasing year by year. Endovascular aneurysm repair(EVAR)is currently the most widely used treatment for infrarenal abdominal aortic aneurysms(AAA). Type Ⅱ endoleak is the most common complication after EVAR and the main reason for secondary postoperative intervention, however, the natural outcome and treatment of type Ⅱ endoleak are still controversial. This paper reviewed the literature on the research progress in the prevention and treatment of type Ⅱ endoleak to provide a reference for clinical decision-making.
    Advances in robotic-assisted endovascular aortic repair
    LIANG Bowen, LU Qingsheng
    Journal of Shandong University (Health Sciences). 2024, 62(9):  61-65.  doi:10.6040/j.issn.1671-7554.0.2024.0321
    Abstract ( 122 )   PDF (2988KB) ( 30 )   Save
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    Endovascular surgical robot has significant advantages in the field of endovascular aortic repair, which can improve the accuracy and efficiency of operation. With the development of artificial intelligence technology, robotic-assisted endovascular aortic repair is developing towards the direction of full-process automation, high efficiency and high safety. In the future, by constructing a three-in-one surgical assistant mode architecture of surgical evaluation, surgical planning and surgical navigation, it is expected to achieve precise, intelligent and minimally-invasive treatment of vascular diseases.
    Research progress of deep learning in automatic segmentation of aortic images
    TANG Yuning, PAN Tianyue, DONG Zhihui, FU Weiguo
    Journal of Shandong University (Health Sciences). 2024, 62(9):  66-73.  doi:10.6040/j.issn.1671-7554.0.2024.0317
    Abstract ( 229 )   PDF (2392KB) ( 94 )   Save
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    In the field of medical image processing, accurate image segmentation is crucial for the diagnosis and treatment planning of aortic diseases. Deep learning techniques, especially convolutional neural networks, have made significant progress in medical image segmentation tasks in recent years. This article reviewed the research on the application of deep learning models to the automatic segmentation of aortic lesion images, summarized the contributions of these current techniques to improving the segmentation accuracy and efficiency, and discussed the challenges faced by existing methods and more possibilities and directions for future research.
    Research progress of ferroptosis in abdominal aortic aneurysm
    NIU Shuai, WU Xuejun
    Journal of Shandong University (Health Sciences). 2024, 62(9):  74-79.  doi:10.6040/j.issn.1671-7554.0.2024.0496
    Abstract ( 175 )   PDF (2219KB) ( 169 )   Save
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    Abdominal aortic aneurysm is a common critical emergency in vascular surgery with a high incidence and a high risk of rupture in the elderly population. However, there is still a lack of effective therapeutic drugs or targets for abdominal aortic aneurysm. Ferroptosis is a newly discovered regulated cell death mode in recent years, characterized by its dependence on the accumulation of iron ions and lipid peroxides. Ferroptosis is widely involved in the development of cardiovascular, neoplastic, neurological and other diseases. This article summarizes the main mechanism of ferroptosis and its role in abdominal aortic aneurysm by reviewing the progress of research related to ferroptosis and abdominal aortic aneurysm in the past five years. Ferroptosis may be involved in the progression of abdominal aortic aneurysm by affecting the senescence, death and phenotype transition of vascular smooth muscle cells, suggesting that ferroptosis may be a new target for the prevention and treatment of abdominal aortic aneurysm.
    Advances in Basic and Clinical Research on Aortic Diseases-Clinical Research
    Spinal cord protection by normothermic auto-arterial bypass and distal-anastomosis-first strategy in thoracoabdominal aortic replacement surgery
    SUN Jing, ZHANG Shuai, QI Hongxia, LI Yuan, ZHOU Yongkang, HU Kejian, QIAN Xiangyang
    Journal of Shandong University (Health Sciences). 2024, 62(9):  80-85.  doi:10.6040/j.issn.1671-7554.0.2024.0313
    Abstract ( 119 )   PDF (4355KB) ( 29 )   Save
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    Objective To summarize the application of the normothermic artery bypass and visceral-anastomosis-first strategy in thoracoabdominal aortic aneurysm(TAAA)repair and to evaluate its spinal cord protective effect, so as to accumulate clinical experience for the implementation of this procedure in thoracoabdominal aortic replacement surgery. Methods We retrospectively analyzed data of patients who underwent thoracoabdominal aortic replacements with normothermic artery bypass and visceral-anastomosis-first strategy at Fuwai Hospital, Chinese Academy of Medical Sciences, between June 2019 and June 2022. Relevant clinical data(baseline data, perioperative indices, and follow-up outcome indices)were collected to assess the overall treatment outcome, as well as the safety and efficacy of the strategy. Results A total of 27 patients with TAAA were treated surgically for TAAA repair using the normothermic autoarterial diversion with a visceral priority strategy. Among them, 2 cases(7.4%)were Crawford classification typeⅠ, 14 cases(51.9%)were type Ⅱ, 9 cases(33.3%)were type Ⅲ, and 2 cases(7.4%)were type Ⅳ. The mean/median time for surgery, postoperative mechanical ventilation, postoperative ICU time, and postoperative hospital stay were(562.5±99.5)min,(30.8±25.3)h, 112.00(69.00, 162.00)min, and(19.8±8.4)d, respectively. One case(3.7%)died within 30 days of surgery, and the remaining patients survived. Acute renal failure was observed in 3 cases(11.1%)and re-thoracotomy due to hemorrhage was performed in 1 case(3.7%). Except for the deceased patient, the remaining 26 patients were followed up for a period from 6 to 56 months with a mean follow-up of(34.0±11.5)months. There were no paraplegia, deaths or other surgical complications during the follow-up period. Conclusion The normothermic artery bypass and visceral-anastomosis-first strategy can be safely and effectively used to treat TAAA and may reduce the incidence of spinal cord injury complications.
    Thoracic endovascular aortic repair with laser in situ fenestration of aortic dissection involving the arch: a single-center clinical outcomes and criteria of stent selection
    DU Guodong, QIU Peng, LIU Junchao, YANG Xinrui, WU Xiaoyu, CUI Chaoyi, QIN Jinbao, ZHAO Zhen, YE Kaichuang, LIU Guang, LIU Xiaobing, YIN Minyi, WANG Ruihua, LU Xinwu
    Journal of Shandong University (Health Sciences). 2024, 62(9):  86-92.  doi:10.6040/j.issn.1671-7554.0.2024.320
    Abstract ( 129 )   PDF (2423KB) ( 55 )   Save
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    Objective To report the clinical outcomes of thoracic endovascular aortic repair with laser in situ fenestration of aortic dissection involving the arch in a single center, and to summarize the clinical experience of stent selection criteria. Methods The clinical data of 330 patients with aortic coarctation involving arch branches treated with thoracic endovascular aortic repair with laser in situ fenestration in our hospital from January 2016 to April 2023 were retrospectively analyzed, including the general information of patients, surgical procedures, technical success rate, and surgical complications. The clinical outcomes were summarized and the selection criteria for aortic stents and branch artery reconstruction stents were analyzed. Results All patients underwent thoracic endovascular aortic repair with laser in situ fenestration, with a mean operation time of(176±51)minutes and a fenestration technique success rate of 98.1%. There were 10 in-hospital deaths(3.03%), 8 symptomatic strokes(2.68%), 41 endoleaks(12.4%), 2 proximal stent-induced new entries(0.61%), and no distal stent-induced new entries were observed. Follow-up CT angiography [(24±7.9)months] demonstrated a branch vessel patency rate of 96.58%. Conclusion Laser in situ fenestration with thoracic endovascular repair of aortic dissection involving the arch is a safe and effective technique with a high success rate and a low complication rate.
    Early results of surgically assisted short-distance retrograde needle puncture technique for in situ fenestration of the aortic arch
    ZHANG Zhiwei, MENG Qingyou, DING Qingwei, ZHANG Xiaoyu
    Journal of Shandong University (Health Sciences). 2024, 62(9):  93-100.  doi:10.6040/j.issn.1671-7554.0.2024.0335
    Abstract ( 121 )   PDF (10473KB) ( 10 )   Save
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    Objective To analyze the early results of the application of surgically assisted short-distance retrograde needle puncture(SDRNP)technique for in situ fenestration in thoracic endovascular aortic repair(TEVAR)in patients with aortic arch disease. Methods A retrospective analysis was performed on 57 patients with aortic arch diseases between March 2021 and March 2023 who underwent TEVAR, and surgically assisted SDRNP in situ fenestration and reconstruction of the superior arch branches. There were 32 cases of aortic dissection, 15 cases of aortic aneurysm and 10 cases of penetrating ulcer. Inclusion criteria were aortic dissection/aneurysm, penetrating ulcer and other arch diseases, insufficient proximal landing zone for TEVAR, and stent graft covering the superior arch branches, and at least one fenestration. Exclusion criteria were the arch disease involving the ascending aorta, less than 20 mm from the opening of the coronary artery, or the diameter of the proximal landing zone greater than 45 mm, or the dominant left vertebral artery originating from the aortic arch. Results The success rate of the surgically assisted SDRNP technique was 98.2%(56/57). In 57 patients, simple left subclavian artery(LSA)fenestration was in 27 patients, LSA+left common carotid artery(LCCA)fenestration was in 18 patients, LCCA + brachiocephalic trunk(BCT)fenestration was in 1 patient, and LSA+LCCA+BCT fenestration was in 11 patients. SDRNP was performed 98 times, LSA 56 times, LCCA 30 times, and BCT 12 times. One patient with type A dissection was scheduled for triple fenestration. However, due to severe LSA distortion, SDRNP in the LSA failed after LCCA+BCT fenestration, and left carotid to left artery-left axillary artery bypass was performed. The mean operative time was(159.1±69.6)min. The mean operative time was(112.4±42.7)min for LSA fenestrations,(165.9±45.7)min for LSA+LCCA fenestrations, and(226.5±79.9)min for LSA+LCCA+BCT fenestrations. Postoperative complications included 1 paraplegia, 2 cerebral infarctions, 1 acute myocardial infarction and 1 limb numbness. Among them, one patient eventually died because of a massive cerebral infarction. Totally 51 patients were followed up with a median follow-up time of 19 months(ranging from 13 to 34 months). Post-operative CTA showed that 5 patients experienced endoleak, including 1 type Ⅰ, 1 type Ⅱ, and 3 type Ⅲ. Two cases with type Ⅲ endoleak were improved by coil embolization after re-intervention. There were no out-of-hospital cerebrovascular events or deaths. Conclusion Surgically assisted SDRNP in situ fenestration of the aortic arch is technically feasible, with the advantages of rapid and efficient manipulation and high success rate of fenestration, yielding acceptable short-term results in selected patient cohorts. However, the long-term effect still needs to be further monitored before the application of this technology can be popularized.
    Risk factors and management for iliac branch occlusion after endovascular abdominal aortic aneurysm repair
    WANG Zheyu, XU Yi, ZHAO Changbo, YANG Shuofei, NI Qihong, CHEN Jiaquan, WANG Weilun, LI Yinan, GUO Xiangjiang, YE Meng, ZHANG Lan, XUE Guanhua
    Journal of Shandong University (Health Sciences). 2024, 62(9):  101-107.  doi:10.6040/j.issn.1671-7554.0.2024.0315
    Abstract ( 138 )   PDF (871KB) ( 47 )   Save
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    Objective To analyze the risk factors of iliac branch occlusion after endovascular aneurysm repair(EVAR)for abdominal aortic aneurysm and the countermeasures. Methods Clinical data of 191 patients with abdominal aortic aneurysm undergoing EVAR admitted to Renji Hospital, Shanghai Jiaotong University School of Medicine between January 2021 and May 2023 were collected. Using a case-control matched design, the cases with and without iliac branch occlusion were matched in a 1∶2 ratio according to gender, age and commercial type of stent used, as the case group(n=26)and control group(n=52). Univariate and conditional Logistic regression analysis was conducted to analyze the risk factors of iliac branch occlusion in the case group compared with the control group. Iliac branch occlusion was treated with thrombolysis, balloon dilatation or stent implantation. Results Iliac branch occlusion occurred in 13.61%(26/191)of the patients after EVAR, and the corresponding treatment was carried out. Among them, 1 patient had another limb occlusion in the contralateral side after 1 month, and 2 patients were given continuation of thrombolysis after thrombus aspiration for 1 day and then balloon dilatation was performed. All patients recovered blood flow from iliac artery after operation. Conditional Logistic regression analysis showed that abdominal aortic bifurcation diameter <20 mm(OR=4.544, 95%CI: 1.397-14.779), preoperative severe distortion of iliac artery before operation(OR=5.971, 95%CI: 1.528-23.336)and calcification of common iliac artery >50%(OR=4.165, 95%CI: 1.189-14.587)were associated with iliac branch occlusion. Conclusion Abdominal aorta diameter <20 mm, severe preoperative distortion of common iliac artery, and calcification of common iliac artery >50% may be independent risk factors for iliac branch occlusion after EVAR. It can be improved obviously after embolectomy, balloon dilatation or stent implantation.
    Single-center experience in treatment of Stanford type B aortic intramural hematoma
    ZHAO Wenpeng, LYU Fanzhen, HU Yiliang, CHEN Shai, FANG Huaqiang, WANG Shizhi, ZHOU Weimin
    Journal of Shandong University (Health Sciences). 2024, 62(9):  108-114.  doi:10.6040/j.issn.1671-7554.0.2024.0322
    Abstract ( 150 )   PDF (4958KB) ( 55 )   Save
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    Objective To evaluate the treatment methods and outcomes for Stanford type B intramural hematoma(IMH). Methods A total of 368 patients with Stanford type B IMH admitted to the Second Affiliated Hospital of Nanchang University from August 2017 to May 2023 were selected for analysis of their clinical data and treatment outcomes. Results Based on the outcomes during follow-up, the patients were divided into the absorption group(n=134)and the progression group(n=234). Univariate analysis showed significant differences between the absorption and progression groups in terms of age [(60.59±11.14)years vs(61.86±12.05)years], platelet count [206.00(88.07)×109/L vs 187.00(86.00)×109/L], aspartate aminotransferase [18.60(19.37)U/L vs 19.50(7.80)U/L], maximum diameter of the descending aorta [35(6)vs 34(5)mm], and distal hematoma involvement of Zone 6-11 [157(66.81%)vs 66(49.25%)](P<0.05). Multivariate Logistic regression analysis indicated that the maximum diameter of the descending aorta was an independent risk factor for the progression of Stanford type B IMH(OR=0.943, 95%CI=0.899-0.990, P=0.017). The average follow-up time for discharged patients was(35.1±17.9)months, with a loss to follow-up rate of 6.8%. The 5-year survival rate post-discharge was 77.4% for the patient with medication treatment and 87.6% for the patient with endovascular treatment. Conclusion Single-center experience suggests that endovascular treatment for Stanford type B IMH is safe and effective. For patients with dilation of the descending aorta, vigilance is required for the progression of intramural hematoma, and surgical intervention may be considered when necessary.
    Single-center experience in diagnosis and treatment of primary aortic thrombosis
    WANG Xiaohan, WU Xuejun, DONG Dianning, WANG Maohua, HAN Zonglin, GAO Peixian, KONG Xiangqian
    Journal of Shandong University (Health Sciences). 2024, 62(9):  115-124.  doi:10.6040/j.issn.1671-7554.0.2024.0603
    Abstract ( 115 )   PDF (10696KB) ( 83 )   Save
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    Objective To explore the diagnosis, treatment and prognosis of primary aortic thrombosis(PAT). Methods Clinical data from 21 patients with PAT treated in the Department of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2017 to December 2023 were retrospectively collected, including gender, age, comorbidities, preoperative and auxiliary examination data, to summarize the information on their clinical characteristics, treatment plan, and follow-up prognosis. Results The first symptom of all the 21 patients was limb or visceral ischemia, including 7 cases of type Ⅱ, 2 cases of type Ⅲ, 9 cases of type Ⅳ, 1 case of type Ⅱ+Ⅲ, 1 case of type Ⅱ+Ⅳ and 1 case of type Ⅲ+Ⅳ. All patients underwent standardized anticoagulation therapy after admission. Among them, 15 patients received surgical thrombectomy or thoracic endovascular aortic repair(TEVAR)and long-term anticoagulant and antiplatelet therapy after surgery, and 6 patients underwent complete anticoagulation and antiplatelet therapy without operation. The median follow-up time was 18 months. During the follow-up period, 1 patient developed symptoms of lower limb ischemia, 2 patients died, and the rest of the patients did not complain of discomfort and did not suffer from recurrence of visceral or lower limb ischemia. Conclusions PAT should be considered for acute limb or visceral ischemia when the source of embolus cannot be determined. If PAT is found, anticoagulation therapy should be applied throughout the course unless there are contraindications to anticoagulation. Continuous pumping of ordinary heparin may have a better effect than low-molecular-weight heparin. TEVAR is significant for the prevention of recurrent embolization, and the postoperative periodical review should be strict, and dynamic observation of PAT lesions should be carried out, so as to avoid reembolism events.