Journal of Shandong University (Health Sciences) ›› 2024, Vol. 62 ›› Issue (9): 74-79.doi: 10.6040/j.issn.1671-7554.0.2024.0496

• Advances in Basic and Clinical Research on Aortic Diseases-Research Progress • Previous Articles    

Research progress of ferroptosis in abdominal aortic aneurysm

NIU Shuai, WU Xuejun   

  1. Department of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China
  • Published:2024-10-10

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Abstract: Abdominal aortic aneurysm is a common critical emergency in vascular surgery with a high incidence and a high risk of rupture in the elderly population. However, there is still a lack of effective therapeutic drugs or targets for abdominal aortic aneurysm. Ferroptosis is a newly discovered regulated cell death mode in recent years, characterized by its dependence on the accumulation of iron ions and lipid peroxides. Ferroptosis is widely involved in the development of cardiovascular, neoplastic, neurological and other diseases. This article summarizes the main mechanism of ferroptosis and its role in abdominal aortic aneurysm by reviewing the progress of research related to ferroptosis and abdominal aortic aneurysm in the past five years. Ferroptosis may be involved in the progression of abdominal aortic aneurysm by affecting the senescence, death and phenotype transition of vascular smooth muscle cells, suggesting that ferroptosis may be a new target for the prevention and treatment of abdominal aortic aneurysm.

Key words: Ferroptosis, Abdominal aortic aneurysm, Vascular smooth muscle cell, Oxidation

CLC Number: 

  • R543.1
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