Effects of evening primrose oil on the metabolism and intestinal flora of obese infertile women
- HAN Xiaoting, YU Xia, DONG Laihui, NA Li, NIU Yanling, ZHAO Junli
Journal of Shandong University (Health Sciences). 2021, 59(2):
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Objective To explore the effects of evening primrose oil on the metabolism and intestinal flora of obese infertile women. Methods A total of 22 obese infertile women were treated with evening primrose oil capsules for one month in the Reproductive Medicine Center of General Hospital of Ningxia Medical University from August 2018 to May 2019. Triglyceride(TG), total cholesterol(TC), high density lipoprotein-cholesterol(HDL-C), low density lipoprotein-cholesterol(LDL-C), fasting blood glucose(FBG), 2-hour postprandial blood glucose(2hPBG), fasting insulin(FINS), 2-hour postprandial insulin(2hPINS), body weight, body mass index(BMI), hip circumference, waist hip ratio(WHR), body fat percentage(PBF), intestinal flora and short chain fatty acids(SCFAs)were compared before and one month after intervention. Results After the intervention, 12 patients complained that the symptoms of seborrhea, snoring, acne, amenorrhea and anovulation were improved. All patients had no oil discharge and other adverse reactions. The results of blood lipid test of 21 patients showed that the levels of TG, TC and LDL-C decreased(P=0.25, 0.10, 0.63, respectively), while the level of HDL-C increased(P=0.48), but there was no significant difference(P>0.05). Blood glucose monitoring was performed in 14 patients, and the results showed that the levels of FBG, 2hPBG, FINS and 2hPINS had no significant changes, with no statistical differences(P=0.38, 0.23, 0.14, 0.56, respectively). The body composition analysis of 9 patients showed that body weight, BMI, hip circumference, WHR and PBF decreased, but there were no statistical differences(P=0.29, 0.41, 0.17, 0.87, 0.38, respectively), while the waist circumference decreased significantly(P=0.04). The results of intestinal flora and SCFAs analysis in 6 patients showed that ACE, Shannon and Simpson indices had no significant changes(P=0.11, 0.67, 0.72, respectively), but the Chaol index decreased(P=0.01). The results of NMDS analysis showed that there was no difference in β diversity. There was no characteristic change of intestinal flora at the level of phylum and genus after intervention(P>0.05). Only caproic acid content in SCFAs decreased(P=0.04). Conclusion Evening primrose oil can improve blood lipid level and obesity-related symptoms in obese infertility women, and the drug is safe, convenient and cheap. Short-term intervention of evening primrose oil has little effects on intestinal flora diversity, abundance and SCFAs.