Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (12): 44-51.doi: 10.6040/j.issn.1671-7554.0.2022.0575

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Association of 4 simple insulin resistance indicators with the risk of hyperuricemia in 698 patients with type 2 diabetes mellitus

ZHAO Meiru1,2,3,4, ZHU Di2,3,4, LIU Lin2,3,4, GUAN Qingbo1,2,3,4, ZHANG Xu2,3,4   

  1. 1. Shandong University, Jinan 250012, Shandong, China;
    2. Department of Endocrine and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;
    3. Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan 250021, Shandong, China;
    4. Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan 250021, Shandong, China
  • Published:2022-12-01

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Abstract: Objective To investigate the effects of triglyceride-glucose(TyG), triglyceride-glucose body mass index(TyG-BMI), triglyceride/high-density lipoprotein cholesterol ratio(TG/HDL-C)and metabolic score for insulin resistance(METS-IR)on the risk of hyperuricemia(HUA)in 698 patients with type 2 diabetes mellitus(T2DM). Methods A total of 698 patients with T2DM hospitalized in the Department of Endocrinology of Shandong Provincial Hospital during Jan. 2016 and Dec. 2019 were selected. According to the serum uric acid value(SUA), the patients were divided into the non-hyperuricemia group(SUA<420 μmol/L, NUA group)and HUA group(SUA≥420 μmol/L, HUA group). The reference value of TyG, TyG-BMI, TG/HDL-C and METS-IR for HUA was analyzed with multivariate Logistic regression and receiver operator characteristic(ROC)curve. Results TyG, TyG-BMI, TG/HDL-C and METS-IR were higher in HUA group than in NUA group(P<0.05). With the occurrence of HUA(assignment: 0=no, 1=yes)as the dependent variable, and the indicators with statistical significance in the univariate regression analysis as the independent variables, the multivariate binary Logistic regression analysis showed that, serum creatinine(Scr), retinol binging protein(RBP), TyG, TyG-BMI, TG/HDL-C and METS-IR were independent influencing factors of HUA in T2DM patients(P<0.05). The ROC curve showed that TyG had the highest reference value on the occurrence of HUA, with the area under the curve(AUC)of 0.73(95%CI: 0.68-0.77), sensitivity of 76.6%, specificity of 57.8 %, and Youden index of 0.34, followed by TyG-BMI, TG/HDL-C and METS-IR. Conclusion TyG, TyG-BMI, TG/HDL-C and METS-IR have reference significance for the occurrence of HUA in middle-aged and elderly male patients with T2DM.

Key words: Triglyceride-glucose index, Triglyceride glucose-body mass index, Triglyceride/high-density lipoprotein cholesterol ratio, Metabolic score for insulin resistance, Hyperuricemia, Type 2 diabetes, Insulin resistance

CLC Number: 

  • R587.1
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