JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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SUN Xue-fei1，CHEN Jing-han2，WANG De-jiang1, LI Xi-bo1   

  1. 1. Department of Thoracic Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;2. Department of Thoracic Surgery, Shandong Provincial Hospital, Jinan 250021, Shandong, China
  • Received:2005-10-09 Revised:1900-01-01 Online:2006-12-24 Published:2006-12-24
  • Contact: SUN Xue-fei

Abstract: To study the effect of Radix Actinidiae extractive on the proliferation of human lung adenocarcinoma cell line A549. Methods： MTT assay and colony formation test were used to detect the effect of drug on cells in vitro. Flow cytometry was used to measure the cell apoptosis and cell cycle. In vivo, the tumor growth curve was drawn and the inhibition ratio was calculated in the athymic mouse bearing A549 cancer cells treated with Radix Actinidiae extractive. Results： Radix Actinidiae extractive can inhibit the A549 cell proliferation in timedependent and dose dependent manner. Flow cytometry displayed that cells in G0＋G1 phases increased and the apoptosis was induced after the Radix Actinidiae extractive treatment. The tumor inhibiting rates of highdose and lowdose group were 71.40% and 40.35％, respectively. The transplanted tumor of treatment group grew slowly and was smaller than that of control group. Conclusion： Radix Actinidiae extractive has anticancer activity on human lung adenocarcinoma cell line A549 and can induce the apoptosis of A549 cells both in vivo and in vitro, and its inhibition in vitro may be related to the blockade of G0＋G1 phases.

Key words: Lung cancer, Apoptosis, Radix Actinidiae extractive, Mice, Inbred BALB

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