Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (8): 99-106.doi: 10.6040/j.issn.1671-7554.0.2021.0301

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Effect of maternal PM10 and PM2.5 exposure during pregnancy on neonatal birth weight

ZHAI Yifan1, WANG Zhaojun2, BAI Shuoxin1, LIN Shaoqian3, WANG Fangyi1, DU Shuang1, WANG Zhiping1   

  1. 1. School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Shandong Jinan Ecological Environment Monitoring Center, Jinan 250000, Shandong, China;
    3. Jinan Municipal Center for Disease Control and Prevention, Jinan 250021, Shandong, China
  • Published:2021-09-16

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Abstract: Objective To explore the association between maternal PM10 and PM2.5 exposure during pregnancy and neonatal birth weight, and further determine the critical window period of maternal PM10 and PM2.5 exposure on neonatal birth weight. Methods The study was based on the baseline study of infant asthma birth cohort in Jinan City, the newborns in the study area were selected as the research subjects, and the birth weight of newborns was obtained. Combined with the particulate matter monitoring data of 17 monitoring stations in Jinan City, the longitude and latitude of the mothers residential address during pregnancy and the longitude and latitude of the monitoring station address, the daily individual exposure concentration of each mother during pregnancy was obtained by using the inverse distance weight method, so as to obtain the exposure dose of each mother during the whole pregnancy, the first trimester, the second trimester and the third trimester. The association between maternal PM10 and PM2.5 exposure during pregnancy and neonatal birth weight was explored by using generalized additive model and negative control exposures analysis method, and the exposure dose of three pregnancy periods were included in the model to find the key window period. Results (1) Totally, 4 602 subjects were included in this study, with an average birth weight of(3 420.98±465.27)g. The average exposure concentrations of PM10 and PM2.5 during pregnancy were 114.15 μg/m3 and 54.71 μg/m3, respectively. (2) For every 10 μg/m3 increase of PM10 and PM2.5 exposure during pregnancy, the birth weight of newborn decreased by 30.46 g (P=0.013)and 51.81 g(P=0.028), respectively; there was no significant association between PM10 and PM2.5 exposure and neonatal birth weight in negative control exposure period(PM10: P=0.166; PM2.5: P=0.650). (3) The results of critical window period analysis showed that the birth weight decreased by 11.56 g(P=0.004)and 43.85 g(P<0.001)for every 10 μg/m3 increase of PM10 and PM2.5 exposure concentration during the first trimester, and decreased by 13.09 g(P=0.001)and 44.04 g(P<0.001)during the third trimester. Conclusion Maternal exposure to PM10 and PM2.5 during pregnancy can reduce neonatal birth weight, and the first trimester and the third trimester are the critical exposure window periods.

Key words: Pregnancy, Inhalable particulate matter, Fine particulate matter, Birth weight, Negative control exposures analysis

CLC Number: 

  • R122.7
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