Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (8): 80-85.doi: 10.6040/j.issn.1671-7554.0.2021.0440

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Effects of valproic acid on the survival and tumor recurrence of 134 patients with glioma treated with radiotherapy

SUN Qingjie1, ZHANG Yisha1, GUAN Shanghui2, FENG Zhihui1   

  1. 1. Department of Occupational and Environmental Health, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Oncology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2021-09-16

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Abstract: Objective To analyze the effects of valproic acid(VPA)on the prognostic survival and tumor recurrence of patients with glioma treated with radiotherapy, so as to provide a clinical basis for the study of the effect of VPA on enhancing the inhibition of tumor growth by radiation and prolonging the survival time of patients. Methods The clinical and follow-up data of 134 glioma patients who underwent surgery and radiotherapy in the Oncology Department of Qilu Hospital, Shandong University during 2012 and 2016 were retrospectively analyzed. The effects of VPA on overall survival(OS)and progression-free survival(PFS)were analyzed with multivariate Cox proportional hazard model. Results The median OS and PFS were 49 and 52 months, respectively. Univariate analysis showed VPA, pathological grade, age and chemotherapy were associated with the prognosis(P<0.05). Multivariate analysis showed, after adjustment of age, pathological grade and the effects of chemotherapy, VPA improved the OS(HR=0.49, 95%CI: 0.30-0.80)and PFS(HR=0.56, 95%CI: 0.33-0.93). Conclusion VPA can significantly prolong the survival time of patients with glioma and reduce tumor recurrence.

Key words: Glioma, Valproic acid, Overall survival, Progression-free survival

CLC Number: 

  • R730.7
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