Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (7): 19-25.doi: 10.6040/j.issn.1671-7554.0.2021.0633

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Related factors of osteoporosis in 210 postmenopausal women with type 2 diabetes mellitus

LYU Li1, JIANG Lu2, CHEN Shihong1, ZHUANG Xianghua1, SONG Yuwen1, WANG Dianhui1, AN Wenjuan1, LI Qian1, PAN Zhe1   

  1. 1.Department of Endocrinology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong, China;
    2. Department of Rheumatism and Immunology, Shengli Oilfield Central Hospital, Dongying 257000, Shandong, China
  • Published:2021-07-16

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Abstract: Objective To investigate the related factors of osteoporosis(OP)in postmenopausal women with type 2 diabetes mellitus(T2DM)and to analyze their predictive value. Methods A total of 337 postmenopausal women with T2DM were selected. According to the results of bone mineral density, the patients were divided into the OP group(n=210)and normal bone mass group(NBM group, n=127). The general data of the subjects were recorded, and indexes such as HbA1c, liver function, kidney function and blood lipid were detected. The bone mineral density was measured with dual-energy X-ray absorptiometry. SPSS 22.0 software was used for statistical analysis. The general data of the two groups were statistically analyzed. Logistics regression was used for multivariate analysis. Pearson correlation analysis was used to analyze the correlation among menopausal duration, age of menarche, age of menopause and other indicators. Receiver operating characteristic(ROC)curve was drawn and the area under the curve(AUC)was calculated to evaluate the value of multivariate regression model in the diagnosis and prediction of OP. Results The age(P<0.001), duration of diabetes(P<0.001), age of menarche(P=0.001)and menopausal duration(P<0.001)in the OP group were higher or longer than those in NBM group, while the body mass index(BMI)in OP group was lower than that in NBM group(P=0.006). Binary Logistic regression results showed that age(OR=1.10, 95%CI=1.01-1.21, P=0.031), menopausal duration(OR=1.17, 95%CI=1.07-1.28, P<0.001), complicated nephropathy (OR=3.52, 95%CI=1.42-8.75, P=0.007)and calcium intake(OR=11.41, 95%CI=4.94-26.34, P<0.001)were risk factors for OP, while BMI(OR=0.86, 95%CI=0.78-0.95, P=0.002)and habitual exercise(OR=0.28, 95%CI=0.13-0.60, P<0.001)were protective factors. The AUC was 0.919; the optimal diagnostic cut-off value was 0.665; the sensitivity and specificity of diagnostic efficacy were 81.3% and 89.8%, respectively. Conclusion Old age, long menopausal duration, complicated nephropathy, low BMI and lack of habitual exercise are the risk factors for OP in postmenopausal women with T2DM. The association between calcium intake and increased risk of OP may be related to the intentional increase in calcium intake.

Key words: Postmenopausal women, Type 2 diabetes mellitus, Osteoporosis, Predictive factor, Menopausal duration

CLC Number: 

  • R587.2
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