Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (2): 48-54.doi: 10.6040/j.issn.1671-7554.0.2020.1360

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Effects of evening primrose oil on the metabolism and intestinal flora of obese infertile women

HAN Xiaoting1, YU Xia1, DONG Laihui1, NA Li1, NIU Yanling1, ZHAO Junli1,2   

  1. 1. Reproductive Medicine Center, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China;
    2. Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan 750004, Ningxia, China
  • Published:2021-03-05

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Abstract: Objective To explore the effects of evening primrose oil on the metabolism and intestinal flora of obese infertile women. Methods A total of 22 obese infertile women were treated with evening primrose oil capsules for one month in the Reproductive Medicine Center of General Hospital of Ningxia Medical University from August 2018 to May 2019. Triglyceride(TG), total cholesterol(TC), high density lipoprotein-cholesterol(HDL-C), low density lipoprotein-cholesterol(LDL-C), fasting blood glucose(FBG), 2-hour postprandial blood glucose(2hPBG), fasting insulin(FINS), 2-hour postprandial insulin(2hPINS), body weight, body mass index(BMI), hip circumference, waist hip ratio(WHR), body fat percentage(PBF), intestinal flora and short chain fatty acids(SCFAs)were compared before and one month after intervention. Results After the intervention, 12 patients complained that the symptoms of seborrhea, snoring, acne, amenorrhea and anovulation were improved. All patients had no oil discharge and other adverse reactions. The results of blood lipid test of 21 patients showed that the levels of TG, TC and LDL-C decreased(P=0.25, 0.10, 0.63, respectively), while the level of HDL-C increased(P=0.48), but there was no significant difference(P>0.05). Blood glucose monitoring was performed in 14 patients, and the results showed that the levels of FBG, 2hPBG, FINS and 2hPINS had no significant changes, with no statistical differences(P=0.38, 0.23, 0.14, 0.56, respectively). The body composition analysis of 9 patients showed that body weight, BMI, hip circumference, WHR and PBF decreased, but there were no statistical differences(P=0.29, 0.41, 0.17, 0.87, 0.38, respectively), while the waist circumference decreased significantly(P=0.04). The results of intestinal flora and SCFAs analysis in 6 patients showed that ACE, Shannon and Simpson indices had no significant changes(P=0.11, 0.67, 0.72, respectively), but the Chaol index decreased(P=0.01). The results of NMDS analysis showed that there was no difference in β diversity. There was no characteristic change of intestinal flora at the level of phylum and genus after intervention(P>0.05). Only caproic acid content in SCFAs decreased(P=0.04). Conclusion Evening primrose oil can improve blood lipid level and obesity-related symptoms in obese infertility women, and the drug is safe, convenient and cheap. Short-term intervention of evening primrose oil has little effects on intestinal flora diversity, abundance and SCFAs.

Key words: Evening primrose oil, Obesity, Infertile women, Intestinal flora

CLC Number: 

  • R711-74
[1] 樊安彤, 田庆, 李欣阳, 等. 女性不孕症患者心理健康状况及其影响因素分析[J]. 山东大学学报(医学版), 2020, 58(1): 106-111. FAN Antong, TIAN Qing, LI Xinyang, et al. Analysis of mental health status and influencing factors of female infertility patients [J]. Journal of Shandong University(Health Sciences), 2020, 58(1): 106-111.
[2] Coussa A, Hasan HA, Barber TM. Impact of contraception and IVF hormones on metabolic, endocrine, and inflammatory status [J]. J Assist Reprod Genet, 2020, 37(4): 1267-1272.
[3] 岳艳, 马亚琳, 张毅, 等. 不孕症女性血清免疫抗体、AMH、FSH水平表达及其临床意义[J]. 中国妇产科临床杂志, 2020, 21(5): 537-538.
[4] 许华, 李亚东, 伏静, 等. 辅助生殖门诊中23317例不孕女性的病因分析[J]. 中华生殖与避孕杂志, 2019, 39(9): 750-755. XU Hua, LI Yadong, ZHANG Yi, et al. Etiology analysis of 23 317 infertile women in asassisted reproduction clinic [J]. Chinese Journal of Reproduction and Contraception, 2019, 39(9): 750-755.
[5] Belan M, Harnois-Leblanc S, Laferrère B, et al. Optimizing reproductive health in women with obesity and infertility [J]. Can Med Asso J, 2018, 190(24): E742-E745.
[6] 吴莉娟, 刘铜华. 肠道菌群在肥胖发病中的地位与作用[J]. 世界科学技术-中医药现代化, 2017, 19(9): 1572-1579. WU Lijuan, LIU Tonghua. The role of gut microbiota in the pathogenesis of obesity [J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 2017, 19(9): 1572-1579.
[7] 薛畅, 李强. 肠道菌群与肥胖关系研究进展[J]. 中国实用内科杂志, 2017, 37(1): 76-79. XUE Chang, LI Qiang. Research progress on the relationship between the gut microbiota and obesity [J]. Chinese Journal of Practical Internal Medicine, 2017, 37(1): 76-79.
[8] Sukkar AH, Lett M, Frost G, et al. Regulation of energy expenditure and substrate oxidation by short-chain fatty acids [J]. J Endocrinol, 2019, 242(2): R1-R8.
[9] Jamilian M, Karamali M, Taghizadeh M, et al. Vitamin D and evening primrose oil administration improve glycemia and lipid profiles in women with gestational diabetes [J]. Lipids, 2016, 51(3): 349-356.
[10] Delitala AP, Capobianco G, Delitala G, et al. Polycystic ovary syndrome, adipose tissue and metabolic syndrome [J]. Arch Gynecol and Obstet, 2017, 296(3): 405-419.
[11] Khalil H, Ellwood L, Lord H, et al. Pharmacological treatment for obesity in adults: an umbrella review [J]. Ann Pharmacother, 2020, 54(7): 695-705.
[12] Khedr NF, Ebeid AM, Khalil RM. New insights into weight management by orlistat in comparison with cinnamon as a natural lipase inhibitor [J]. Endocrine, 2020, 67(12): 109-116.
[13] 刘永健, 李凌鸥, 程菲菲, 等. 奥利司他对比二甲双胍降低超体质量或肥胖患者体质量疗效和安全性的Meta分析[J]. 中国药房, 2018, 29(5): 690-694. LIU Yongjian, LI Lingou, CHENG Feifei, et al. Efficacy and Safety of Orlistat versus Metformin in Reducing Body Weight of Overweight or Obese Patients:A Meta-analysis [J]. China Pharmacy, 2018, 29(5): 690-694.
[14] 蒋琪, 贺婷婷, 石玉华. 奥利司他治疗肥胖型多囊卵巢综合征的研究进展[J]. 中华生殖与避孕杂志, 2019, 39(9): 763-767. JIANG Qi, HE Tingting, SHI Yuhua. Research progress of orlistat on metabolic and ovulatory disorders in obese polycystic ovary syndrome patients [J]. Chinese Journal of Reproduction and Contraception, 2019, 39(9): 763-767.
[15] 欧明, 王宁生. 中药及其制剂不良反应大典[M]. 沈阳: 辽宁科学技术出版社, 2002: 220.
[16] 孟磊, 王丹. EPA和DHA对高脂血症大鼠作用的实验研究[J]. 锦州医科大学学报, 2019, 40(2): 21-23. MENG Lei, Wang Lei. Experimental Study on the Preventive and Therapeutic Effects of EPA and DHA on Hyperlipidemia [J]. Journal of Jinzhou Medical University, 2019, 40(2): 21-23.
[17] 吴一仙, 李依秋, 周怡婷, 等. 月见草油透皮吸收对小鼠体重增长抑制效果的研究[J]. 中国油脂, 2019, 44(10): 100-104. WU Yixian, LI Yiqiu, ZHOU Yiting, et al. Inhibition effect of transdermal absorption of evening primrose oil on body weight growth of mice [J]. China Oils and Fats, 2019, 44(10): 100-104.
[18] 陈维, 关乐, 蒋亦昕. 月见草油-姜黄素微胶囊制备及对动脉硬化大鼠脂质代谢初探[J]. 辽宁中医药大学学报, 2018, 20(6): 28-31. CHEN Wei, GUAN Le, JIANG Yixin. Preparation of primrose oil-curcumin microcapsules and its study on lipid metabolism in arteriosclerosis rats [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2018, 20(6): 28-31.
[19] 刘杰, 卿德刚, 张娟, 等. 复方月见草油软胶囊对高血脂人群的影响[J]. 中国实验方剂学杂志, 2013, 19(5): 324-326. LIU Jie, LI Yulan, ZHANG Juan, et al. Study on influences of compound scabish oil soft capsule on hyperlipidemia people [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2013, 19(5): 324-326.
[20] 金在久, 姜艳玲, 张善玉. 月见草油合剂对糖尿病小鼠糖脂代谢及抗氧化作用的影响[J]. 中国老年学杂志, 2011, 31(1): 111-113.
[21] Masoud K, Meysam Z, Omid MM, et al. Effect of evening primrose oil supplementation on lipid profile: A systematic review and meta-analysis of randomized clinical trials [J]. Phytother Res, 2020, 34(10): 2628-2638.
[22] Julia G, Hans D, Gerard H, et al. Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations [J]. Br J Nutr, 2008, 99(2): 360-369.
[23] 王海琦, 崔鸿峥, 李畅, 等. 月见草油调节p38MAPK、NF-κB信号通路抗炎治疗痤疮的实验[J]. 中药药理与临床, 2018, 34(2): 62-67. WANG Haiqi, CUI Hongzheng, LI Chang, et al. Evening primrose oil regulates p38MAPK and NF-κB signaling pathway for anti-inflammatory treatment of acne [J]. Pharmacology and Clinics of Chinese Materia Medica, 2018, 34(2): 62-67.
[24] Atteia HH, Alzahrani S, El-Sherbeeny NA, et al. Evening primrose oil ameliorates hyperleptinemia and reproductive hormone disturbances in obese female rats: impact on estrus cyclicity [J]. Front Endocrinol(Lausanne), 2019, 10: 942. doi:10.3389/fendo.2019.00942.
[25] Nasri K, Akrami S, Rahimi M, et al. The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial [J]. Endocr Res, 2018, 43(1): 1-10.
[26] 温潇潇, 麦劲壮, 高向民, 等. 成人中心性肥胖的腰围切点分析[J]. 中华心血管病杂志, 2015, 43(9): 822-826. WEN Xiaoxiao, MAI Jinzhuang, GAO Xiangmin, et al. Cut-off values of waist circumference for central obesity in Chinese adults [J]. Chinese Journal of Cardiology, 2015, 43(9): 822-826.
[27] Shen T D. Diet and gut microbiota in health and disease [J]. Nestle Nutr Inst workshop Ser, 2017, 88: 117-126. doi:10.1159/000455220.
[28] Le Chatelier E, Nielsen T, Qin J, et al. Richness of human gut microbiome correlates with metabolic markers [J]. Nature, 2013, 500(7464): 541-546.
[29] Chen G, Zhuang J, Cui Q, et al. Two bariatric surgical procedures differentially alter the intestinal microbiota in obesity patients [J]. Obes Surg, 2020, 30(10): 2345-2361.
[30] 费嘉, 罗军涛, 章小英, 等. 短链脂肪酸在肠道菌群调节人体能量代谢中的作用[J]. 中华糖尿病杂志, 2018, 10(5): 370-373.
[31] Mueller NT, Zhang M, Juraschek S P, et al. 785-P: Effects of metformin and behavioral weight loss on serum short-chain fatty acids(SCFAs)[J]. Diabetes, 2019, 68. doi:10.2337/db19-785-P.
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