JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (6): 124-128.doi: 10.6040/j.issn.1671-7554.0.2016.1270

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The relationship between γ-glutamyltransferase and hyperuricemia: a cohort study

CAO Jin1, JI Xiaokang2, SUN Xiubin1, JIANG Zheng1, XUE Fuzhong1   

  1. 1. Department of Epidemiology and Biostatistics;
    2. Information and Data Analysis Lab, School of Public Health, Shandong University, Jinan 250012, Shandong, China
  • Received:2016-10-08 Online:2017-06-10 Published:2017-06-10

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Abstract: Objective To explore the relationship between γ-glutamyltransferase(GGT)and hyperuricemia(HUA). Methods We selected 26,006 participants from the routine health check-up system in the “large sample longitudinal health management cohort data management system” as baseline to follow up and to construct the longitude cohort. After that, we divided GGT into four levels(Q1, Q2, Q3, Q4), and adopted Cox regression model to explore the relationship between GGT and HUA. Results The incidence density of HUA was 74.4/1 000 personyears. The Cox model adjusted age showed that relative hazards(RRs)of different levels(Q2, Q3, Q4)compared with the lowest level(Q1)were 1.64(95%CI: 1.46-1.84, P<0.001), 2.24(95%CI: 2.00-2.50, P<0.001), 2.68(95%CI: 2.41-2.99, P<0.001), respectively. After the age, BMI, systolic blood pressure, triglyceride, total cholesterol, high-density lipoprotein cholesterol and serum creatinine were adjusted, the RRs were 1.20(95%CI: 1.04-1.38, P<0.001), 1.43(95%CI:1.24-1.64, P<0.001), 1.51(95%CI: 1.31-1.74, P<0.001), respectively. After further adjusting for smoking and drinking, the RRs were 1.19(95%CI: 1.04-1.37, P<0.001), 1.41(95%CI:1.23-1.62, P<0.001), 1.49(95%CI: 1.29-1.72, P<0.001), respectively. Conclusion GGT is an independent risk factor of HUA. With the enhanced GGT level, the risk of developing HUA will increase.

Key words: Hyperuricemia, γ-glutamyltransferase, Cohort study, Cox model

CLC Number: 

  • R589
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