JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (6): 37-41.doi: 10.6040/j.issn.1671-7554.0.2017.367

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Sub-distribution hazard model and its applications in health risk assessment

WANG Jintao1,2,3, SU Ping2,3, YUAN Zhongshang2,3, XUE Fuzhong2,3   

  1. 1. Department of Statistics, School of Mathematics and Statistics, Shandong University, Weihai 264200, Shandong, China;
    2. Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    3. Cheeloo Research Center for Biomedical Big Data, Shandong University, Jinan 250012, Shandong, China
  • Received:2017-04-27 Online:2017-06-10 Published:2017-06-10

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Abstract: Objective To introduce the theory of sub-distribution hazard model and its applications in health risk assessment. Methods Given that competing risks are commonly encountered in health risk assessment, we have introduced the sub-distribution hazard model, and further evaluate itsefficiency and application based on the Shandong Multi-center cohort of hemorrhagic cerebral apoplexy. Results Under the framework of competing risk, the sub-distribution hazard model took the competing endpoint into the construction of the risk set, other than treating the competing endpoint simply as the censoring. Thus, it can have better performance than the traditional Cox model. Based on the Shandong Multi-center cohort of hemorrhagic cerebral apoplexy, it showed a good practicability in risk assessment of stroke death. Conclusion The sub-distribution hazard model can directly link the covariates with the cumulative incidence function, and can efficiently deal with the competing risk problem.

Key words: Health risk assessment, Cox model, Sub-distribution hazard model, Competing risks

CLC Number: 

  • R195
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