JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (6): 42-46.doi: 10.6040/j.issn.1671-7554.0.2017.368

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Cause-specific hazard model and its applications in health risk assessment

WANG Tingting1,2, WANG Jintao1,2,3, YUAN Zhongshang1,2, SU Ping1,2, XUE Fuzhong1,2   

  1. 1. Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Cheeloo Research Center for Biomedical Big Data, Shandong University, Jinan 250012, Shandong, China;
    3. Department of Statistics, School of Mathematics and Statistics, Shandong University, Weihai 264200, Shandong, China
  • Received:2017-04-27 Online:2017-06-10 Published:2017-06-10

Abstract: Objective To introduce the theory of cause-specific hazard model and its applications in health risk assessment. Methods Given that competing risks are commonly encountered in health risk assessment, we have introduced the cause-specific hazard model from the perspective of modeling principle and parameter estimator, and further evaluate the efficiency and application based on the Shandong Multi-center cohort of hemorrhagic cerebral apoplexy. Results Under the framework of competing risk, the cause-specific hazard model constructed the cox-type survival model for each cause-specific endpoint. The parameter estimator can be obtained from the partial likelihood and thus have good properties, this can make sure that the absolute risk is accurate. Based on the Shandong Multi-center cohort of hemorrhagic cerebral apoplexy, it showed a good practicability in risk assessment of stroke death. Conclusion When competing risk can not be ignored, the cause-specific hazard model are preferred in health risk assessment.

Key words: Health risk assessment, Competing risks, Cox model, Cause-specific hazard model

CLC Number: 

  • R195
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